Canada Drugs Direct

Visiting from Canada?

Want to save up to 80% on your medications? Signup below to be notified if we open a Canadian Online Pharmacy.

I agree to receive email updates from Canada Drugs Direct

Looking for Call us toll free 1-800-500-2897

Motilium (Domperidone)

Prescription medicineOnly Available By Prescription

Top Generic choice

Strength Pack Size Qty
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Your doctor may prescribe Motilium to treat delayed gastric emptying. Symptoms can include fullness, bloating, abdominal pain, abdominal swelling, nausea, and vomiting.

It works by blocking dopamine receptors in the gastrointestinal tract. Dopamine blockade increases the contraction of the muscles at the lower end of the esophagus and prevents the stomach contents from flowing back into the esophagus.

Fact Table




US DailyMed


Oral: 13–17%

Legal status


Chemical Name


Elimination half-life

7–9 hours

Dosage (Strength)



Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


The usual dosage is 10 mg by mouth three times daily with meals. The dosage can be increased to 10 mg four times daily if needed.

Take 15-30 minutes before meals.


The active ingredient in Motilium is Domperidone.


Tell your doctor about all medications you are taking, including:

  • Adagrasib
  • Anticholinergic Agents
  • Atazanavir
  • Bromocriptine
  • Ceritinib
  • Clarithromycin
  • Cobicistat and cobicistat-containing coformulations
  • Darunavir
  • Fosfomycin
  • Fusidic Acid (Systemic)
  • Haloperidol
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Lefamulin
  • Levoketoconazole
  • Levoketoconazole
  • Levosulpiride
  • Lonafarnib
  • Lopinavir
  • Mifepristone
  • Monoamine Oxidase Inhibitors
  • Nefazodone
  • Nelfinavir
  • Nirmatrelvir-ritonavir
  • Ombitasvir-paritaprevir-ritonavir
  • Ombitasvir-paritaprevir-ritonavir plus dasabuvir
  • Ondansetron
  • Opioid Agonists
  • Pentamidine (Systemic)
  • Pimozide
  • Posaconazole
  • Posaconazole
  • QT-prolonging Agents
  • Ritonavir and ritonavir-containing coformulations
  • Saquinavir
  • Sertindole
  • Sirolimus
  • Telithromycin
  • Tucatinib
  • Voriconazole


Tell your doctor if you have a history of liver or kidney disease, gastrointestinal bleeding, or pituitary gland tumor, as Motilium may worsen these conditions.

Motilium may interact with other medications, including antibiotics, antifungal medications, and medications for heart rhythm disorders. It is important to inform your doctor of all your medications before starting treatment with Motilium. This effect is especially prominent in older adults.

Do not use Motilium if you are pregnant or breastfeeding unless you speak to your doctor first.

Side Effects

The most common side effects include

  • Abdominal cramps
  • Acid regurgitation
  • Asthenia
  • Change in appetite
  • Constipation
  • Diarrhea
  • Dizziness
  • Galactorrhea not associated with childbirth
  • Gynecomastia
  • Headache
  • Heartburn
  • Hot flash
  • Increased serum cholesterol
  • Increased serum prolactin
  • Increased thirst
  • Insomnia
  • Irritability
  • Lethargy
  • Migraine
  • Nausea
  • Nervousness
  • Stomatitis
  • Xerostomia


  1. Motilium [package insert]. Auckland, NZ: Johnson and Johnson; 2022.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product-reviews Product Reviews