Moduretic (Amiloride/HCTZ)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Moduretic is a prescription drug that treats high blood pressure with or without heart failure. It contains two different active ingredients. They are both diuretics that reduce the workload on the heart.

Hypertension is a chronic condition that can cause organ damage or cardiovascular events like heart attack and stroke.

Heart failure is a condition where the heart cannot pump hard enough to efficiently move blood through the body.

Fact Table






Readily absorbed, 15–25%

Legal status


Chemical Name


Elimination half-life

6 to 9 hours

Dosage (Strength)



Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


The starting Moduretic dose is one tablet by mouth once daily. Your doctor may choose to increase the dose to two tablets by mouth every day.

Take Moduretic exactly as prescribed by your doctor.


The only available strength of Moduretic is Moduretic 5-50 mg, which is amiloride 5 mg, and hydrochlorothiazide 50 mg.

Hydrochlorothiazide is a thiazide diuretic. It causes the kidneys to excrete extra sodium, carrying fluid with it. The net effect is lower blood pressure and lower stress on the heart.

Amiloride is a potassium-sparing diuretic. It works in a similar way to hydrochlorothiazide but helps the kidneys hold onto potassium so that it isn't excreted with sodium.


Common drug-drug interactions with Moduretic can include:

  • Bile acid sequestrants
  • Cyclosporine
  • Dofetilide
  • Eplerenone
  • Lithium
  • Obinutuzumab
  • Potassium salts
  • Promazine
  • Spironolactone
  • Topiramate


Your doctor should monitor for electrolyte imbalances while you are taking this medication.

You may be more sensitive to the sun while taking this drug.

Use caution if you have a personal or family history of gout.

Tell your doctor if you have an allergy to sulfa drugs.

This is not a full list of precautions. Talk to your doctor or pharmacist to learn more.

Side Effects

Common side effects with Moduretic may include:

  • Dizziness
  • Headache
  • Hyperkalemia
  • Nausea
  • Skin rash
  • Weakness


  1. Morgantown, WV: Mylan; 2020.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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