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Minivelle (Estradiol transdermal System)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
0.025mg (1 package of 8 patches)
Pack Size
0.025mg (1 package of 8 patches)
Pack Size
0.0375mg (1 package of 8 patches)
Pack Size
0.0375mg (1 package of 8 patches)
Pack Size
0.05mg (1 package of 8 patches)
Pack Size
0.075mg (1 package of 8 patches)
Pack Size
0.075mg (1 package of 8 patches)
Pack Size
0.1mg (1 package of 8 patches)
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Minivelle patch is a transdermal medication that can be applied to the skin to treat symptoms of menopause. It is effective for the treatment of vasomotor symptoms, which can include: hot flashes and night sweats.

Minivelle works by replacing the estrogen lost through the natural process of menopause. By replacing the low estrogen, it relieves symptoms of hot flashes and night sweats.

Fact Table






Less than 5%

Legal status


Chemical Name


Elimination half-life

Oral: 13–20 hours

Dosage (Strength)

0.025mg, 0.0375mg, 0.05mg, 0.075mg, 0.1mg


Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration

Oral, sublingual, intranasal, topical/transdermal, vaginal, intramuscular or subcutaneous (as an ester), subdermal implant


The standard dosage is Minivelle 0.375 mg twice weekly. The dose can be adjusted based on your response to the medication.


The active ingredient in the Minivelle dose patch is estradiol.


Talk to your doctor if you experience any of the following while taking Minivelle.

  • Abametapir
  • Anastrozole
  • Cosyntropin
  • Dehydroepiandrosterone
  • Exemestane
  • Fexinidazole
  • Fusidic Acid
  • Growth hormone analogs
  • Hemin
  • Indium 111 capromab pendetide
  • Ospemifene
  • TiZANidine
  • Tranexamic acid


Tell your doctor if you have a history of clotting disorders like Deep Vein Thrombosis, Pulmonary Embolism, and heart attack before taking this medication.

You may be at an increased risk of certain types of cancers if you take this drug, including endometrial, uterine, and breast cancers.

Side Effects

Minivelle and other estrogen products have many different potential side effects; tell your doctor and pharmacist if you are getting any of the following:

  • Abdominal distention
  • Abdominal pain
  • Abnormal uterine bleeding
  • Accidental injury
  • Acne vulgaris
  • Anxiety
  • Arthralgia
  • Asthenia
  • Back pain
  • Breakthrough bleeding
  • Breast hypertrophy
  • Breast tenderness
  • Bronchitis
  • Cervical polyp
  • Constipation
  • Depression
  • Dizziness
  • Dysmenorrhea
  • Dyspepsia
  • Edema
  • Endometrium disease
  • Fatigue
  • Flatulence
  • Flu-like symptoms
  • Fungal infection
  • Gastroenteritis
  • Headache
  • Hirsutism
  • Hot flashes
  • Hypertension
  • Intermenstrual bleeding
  • Leukorrhea
  • Limb pain
  • Mastalgia
  • Myalgia
  • Nasopharyngitis
  • Nausea
  • Neck pain
  • Nipple pain
  • Pain
  • Paranasal sinus congestion
  • Pharyngitis
  • Pruritus
  • Rhinitis
  • Sinus headache
  • Sinusitis
  • Skin rash
  • Upper respiratory tract infection
  • Urinary tract infection
  • Uterine pain
  • Vaginal discharge
  • Vaginal hemorrhage
  • Vaginal mycosis
  • Vulvovaginal candidiasis
  • Weight gain


Minivelle (Estradiol). Miami, FL: Noven Pharmaceuticals Inc.; 2012.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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