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Migranal Nasal Spray (Dihydroergotamine)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
4mg/ml (3 x 1ml)
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Dihydroergotamine mesylate nasal spray can be prescribed by your doctor for the treatment of the following conditions:

  • Cluster headache
  • Moderate to severe migraine

This drug is usually used after other migraine medications have been tried and failed.

Dihydroergotamine mesylate works by activating serotonin receptors on the surface of blood vessel cells in the brain. By activating these receptors, it causes the relaxation of vessels and reduces pain levels.

Fact Table







Legal status


Chemical Name


Elimination half-life

9 hours

Dosage (Strength)



Consult Doctor


Migranal, Trudhesa

Protein binding


PubChem CID






ATC code






Routes of administration



Take this drug exactly as prescribed by your doctor. Using it more often than prescribed can lead to rebound headaches and worsening of your current condition.

The standard dose is 1 mg inhaled as a single dose, which may be repeated every hour as needed. The maximum daily dose is 3 mg in 24 hours and 6 mg in one week.


The active ingredient in this drug is Dihydroergotamine Mesylate.


There are many potential drug-drug interactions, including:

  • Abametapir
  • Alpha-/Beta-Agonists
  • Alpha1-Agonists
  • Bromocriptine
  • Atazanavir
  • Ceritinib
  • Clarithromycin
  • Cobicistat and cobicistat-containing coformulations
  • Darunavir
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Levoketoconazole
  • Lonafarnib
  • Lopinavir
  • Mifepristone
  • Nefazodone
  • Nelfinavir
  • Ombitasvir-paritaprevir-ritonavir
  • Ombitasvir-paritaprevir-ritonavir plus dasabuvir
  • Posaconazole
  • Ritonavir and ritonavir-containing coformulations
  • Saquinavir
  • Telithromycin
  • Tucatinib
  • Voriconazole
  • Erythromycin 
  • Fosamprenavir
  • Roxithromycin
  • Triptans
  • Tipranavir
  • Nitroglycerin


Tell your doctor if you have a history of heart conditions before starting this drug. 

Use caution if you have a prior history of stroke, as this medication has been known to cause cerebral hemorrhage in certain people.

Side Effects

The most common dihydroergotamine mesylate nasal spray side effects may include:

  • Altered sense of smell
  • Asthenia
  • Burning sensation of the nose
  • Diarrhea
  • Drowsiness
  • Dry nose
  • Dysgeusia
  • Ear discomfort
  • Epistaxis
  • Hot flash
  • Nasal cavity pain
  • Nasal congestion
  • Nasal discomfort
  • Nasal mucosal irritation
  • Nasal sore
  • Nasopharyngitis
  • Nausea
  • Pharyngitis
  • Rhinitis
  • Rhinorrhea
  • Sinus discomfort
  • Stiffness
  • Vomiting


Dihydroergotamine. East Hanover, New Jersey: Novartis; year.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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