Canada Drugs Direct

Visiting from Canada?

Want to save up to 80% on your medications? Signup below to be notified if we open a Canadian Online Pharmacy.

I agree to receive email updates from Canada Drugs Direct

Looking for Call us toll free 1-800-500-2897

Mektovi (Binimetinib)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Mektovi is an oral kinase inhibitor primarily prescribed for the treatment of unresectable or metastatic melanoma with a BRAF V600E or V600K mutation. It is indicated for treatment in combination with encorafenib.

Mektovi is a reversible inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activity. By blocking these proteins, Mektovi inhibits the growth of cancer cells.


The recommended dosage is 45 mg by mouth twice daily in combination with encorafenib. Mektovi can be taken with or without food.

Tell your doctor if you have a history of liver disease. They may need to adjust your Mektovi dose to 30 mg twice daily.

Do not stop or adjust the dosage of Mektovi without speaking to your doctor.


The active ingredient in Mektovi is binimetinib.


There are no significant drug-drug interactions between Mektovi and other medications.


Tell your doctor if you have a history of heart disease starting treatment. Your doctor should assess your heart function before starting treatment, after one month, and then every 2-3 months thereafter.

Tell your doctor if you have a history of a clotting disorder.

Use caution if you have a history of eye disease, lung disease, liver disease, musculoskeletal disease, or bleeding disorders.

Do not Mektovi if you are pregnant or planning to become pregnant.

Side Effects

Common adverse reactions may include:

  • Abdominal pain
  • Bleeding from anus
  • Bleeding hemorrhoids
  • Cancer
  • Cardiomyopathy
  • Central serous chorioretinopathy
  • Cough (Non-small cell lung cancer)
  • Diarrhea
  • Dyspnea (Non-small cell lung cancer)
  • Fatigue
  • Hemothorax
  • Hematochezia
  • Hemorrhage
  • Intracranial hemorrhage, Fatal
  • Left ventricular cardiac dysfunction
  • Musculoskeletal pain (Non-small cell lung cancer)
  • Nausea
  • Papilloma (Non-small cell lung cancer)
  • Pulmonary embolism
  • Rectal hemorrhage
  • Squamous cell carcinoma of the skin (Non-small cell lung cancer)
  • Thrombosis of retinal vein
  • Uveitis
  • Vomiting
  • Venous thromboembolism


Mektovi [package insert]. Boulder, CO: Array BioPharma; June 2018.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product-reviews Product Reviews