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Strength
10mg
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
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Mavenclad (cladribine) is an oral immunosuppressive treatment indicated for adults with relapsing forms of multiple sclerosis (RMS), including relapsing-remitting disease and active secondary progressive disease. It is not recommended for patients with clinically isolated syndrome (CIS). Cladribine is a purine nucleoside analog that selectively targets lymphocytes, resulting in a reduction of B and T cell counts associated with MS disease activity. Its unique intermittent dosing schedule offers long-term effects on disease progression with limited cumulative exposure.
| Fact Table | |
| Formula | C10H12ClN5O3 |
| License | US FDA, EMA |
| Bioavailability | 37%–51% |
| Legal status | Prescription only (Rx) |
| Chemical Name | 2-chlorodeoxyadenosine |
| Elimination half-life | 5.4–19.7 hours |
| Dosage (Strength) | 10 mg oral tablets (administered in treatment cycles) |
| Pregnancy | Contraindicated; avoid pregnancy during and 6 months after treatment |
| Brands | Mavenclad |
| Protein binding | 20% |
| PubChem CID | 2019 |
| MedlinePlus | a618009 |
| ChEBI | 3693 |
| ATC code | L01BB04 |
| DrugBank | DB00242 |
| KEGG | D00775 |
| Routes of administration | Oral, intravenous (off-label/other indications) |
Mavenclad is administered orally in two annual treatment courses, each consisting of two treatment weeks:
Each treatment week includes 4 or 5 consecutive days of once-daily dosing, depending on the patient's weight.
Total dose per year: 3.5 mg/kg body weight, divided into 1.75 mg/kg per treatment week.
Doses are taken with water and can be taken with or without food. Tablets should be swallowed whole and not handled with bare hands. Antiviral prophylaxis is recommended if lymphocyte counts fall below 200 cells/µL.
Before initiation, a full blood count, HIV screening, hepatic and renal function tests, cancer screening, and varicella zoster virus immunity assessment should be completed. Women of childbearing potential must have a negative pregnancy test prior to starting and use effective contraception during treatment and for at least 6 months after the last dose.
Active ingredient: cladribine
Inactive ingredients: hydroxypropylbetadex, sorbitol, magnesium stearate, and sodium stearyl fumarate. The tablet coating includes polyvinyl alcohol, titanium dioxide, polyethylene glycol, and talc.
Mavenclad is contraindicated in patients with:
Current malignancy
HIV infection
Active chronic infections (e.g., hepatitis or tuberculosis)
Pregnancy and breastfeeding
Moderate to severe renal impairment
Immunocompromised states
Lymphopenia is common and can lead to opportunistic infections such as herpes zoster. Monitoring of lymphocyte counts is critical before and during treatment. There is a theoretical risk of malignancy due to immunosuppression; patients should undergo appropriate cancer screening before initiation and during follow-up. Live attenuated vaccines should be avoided during treatment and until immune function has recovered. Use with other immunosuppressive or myelosuppressive agents may increase the risk of toxicity and is not recommended.
Common side effects may include:
Headache
Nausea
Lymphopenia
Upper respiratory tract infection
Herpes zoster
Rash
Fatigue
Alopecia (less common)
Serious adverse events include severe lymphopenia, infections, and malignancy risk, requiring regular monitoring and individualized risk-benefit assessment.
Is Mavenclad a cure for MS?
No, Mavenclad is not a cure for multiple sclerosis. However, it can significantly reduce relapse rates, slow disability progression, and reduce new brain lesions in people with relapsing forms of MS.
Can Mavenclad be taken with other MS medications?
Usually, no. Because Mavenclad affects the immune system, it’s not recommended to take it with other disease-modifying therapies (DMTs). Your doctor will likely stop other MS meds before starting Mavenclad.
What are the most common side effects of Mavenclad?
Common side effects include:
Monitoring blood counts is a key part of treatment.
How often do I need blood tests while on Mavenclad?
You’ll need regular blood tests before, during, and after treatment. These help monitor your lymphocyte (white blood cell) levels, as well as liver and kidney function and infection risk.
Can I drink alcohol while on Mavenclad?
There are no strict alcohol restrictions, but moderation is recommended. Since Mavenclad can affect your liver and immune system, you should talk to your doctor about safe alcohol use during treatment.
Will I lose all my immunity after taking Mavenclad?
No, but your immune system will be temporarily suppressed. It doesn’t eliminate your entire immune system—it selectively reduces lymphocytes. Most people maintain some immune protection, but your doctor will monitor your levels closely.
Can I travel during Mavenclad treatment?
Yes, but you should be cautious. Avoid areas with high infection risk and make sure you’re up to date on vaccines (non-live) before treatment. Also, travel insurance and access to medical care are important if you’re going abroad.
How is Mavenclad different from other MS drugs?
Mavenclad is unique because it’s:
Unlike daily or weekly treatments, Mavenclad is a low-burden option for many patients.
What happens after the 2-year Mavenclad treatment course?
After two years, no additional Mavenclad doses are given unless relapse activity returns. Many patients remain stable for several years after completing the initial treatment, though some may eventually need additional MS therapy.
Who should not take Mavenclad?
Mavenclad is not recommended for people who:
Your doctor will do a full assessment to ensure it’s safe for you.
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