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Matulane (Procarbazine)

Prescription medicineOnly Available By Prescription

Top Generic choice

Strength Pack Size Qty
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


MATULANE (procarbazine) is a prescription medication used to treat certain types of cancer. MATULANE is a chemotherapy drug and should only be used under the close supervision of an oncologist.

MATULANE is indicated to treat Hodgkin lymphomas but can be used off-label to treat CNS tumors, Non-Hodgkin lymphomas, and primary CNS lymphoma. It is used in combination with other medications as part of a standard regimen.

Fact Table







Legal status


Chemical Name


Elimination half-life

10 minutes

Dosage (Strength)



Not recommended


Matulane, Natulan

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


The oncologist will determine the dosage and directions for MATULANE. It is available in 50 mg capsules.


The active ingredient in MATULANE is procarbazine.


Chemotherapy drugs have many different possible drug-drug interactions. The interactions with the highest severity include:

  • BCG
  • Cladribine
  • Deferiprone
  • Dipyrone
  • Echinacea
  • Fingolimod
  • Inactivated vaccines
  • Iohexol
  • Iomeprol
  • Iopamidol
  • Leflunomide
  • Lenograstim
  • Lipefilgrastim
  • Live vaccines
  • Natalizumab
  • Nivolumab
  • Palifermin
  • Pimecrolimus
  • Roflumilast
  • Sipuleucel-T
  • Tacrolimus
  • Tofacitinib
  • Upadacitinib
  • Varicitinib

Speak with your oncologist or pharmacist to learn the full list of drug interactions with MATULANE.


MATULANE and other chemotherapy drugs cause bone marrow suppression, which should be monitored throughout treatment.

Do not drink alcohol while taking this medication.

MATULANE has a high risk of gastrointestinal side effects, including nausea, vomiting, stomatitis, and diarrhea.

The risk of bleeding is increased while taking MATULANE.

Side Effects

Common MATULANE side effects can include:

  • Black, tarry stools
  • Bone, joint, and muscle pain
  • Confusion
  • Constipation
  • Diarrhea
  • Difficulty sleeping
  • Dizziness
  • Dry mouth
  • Fainting
  • Hair loss
  • Hallucinations
  • Headache
  • Low appetite
  • Nausea
  • Prickling or tingling of the hand or feet
  • Seizures
  • Sores in the mouth and throat
  • Stomach pain
  • Tremor
  • Vision changes
  • Vomiting
  • Yellowing of the skin or eyes


Matulane [package insert]. Wilmington, NC: Leadiant Biosciences; 2019.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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