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Malarone(Atovaquone + Proguanil)

Prescription medicineOnly Available By Prescription

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Strength Pack Size Qty
Pediatric 62.5mg/25mg
Pack Size
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


MALARONE (Atovaquone + Proguanil) Is a combination prescription product effective against malaria. It can be used for the prevention or treatment of malaria.

MALARONE is one of many different anti-malarial drugs given to travelers before they depart to countries with high malaria rates.

If someone becomes actively infected with malaria, MALARONE is a possible treatment option.


The MALARONE dosing depends on why it is being taken:

  • Malaria prevention: Take one tablet (atovaquone 250 mg/proguanil 100 mg) once daily, 1 to 2 days before entering an area with malaria. Continue for 7 days after leaving the area.
  • Malaria treatment: Take four tablets once daily for 3 days.


The active ingredients in MALARONE are atovaquone and proguanil.

Atovaquone works in the mitochondria of malarial cells. It prevents the mitochondria from functioning, which inhibits key cellular processes, killing the parasite.

Proguanil inhibits dihydrofolate reductase, which is a critical enzyme in the metabolic pathway of malarial cells. Proguanil prevents the malarial parasite from developing inside the liver prior to infecting red blood cells. 


  • Antipsychotics
  • Dapsone
  • Efavirenz
  • Ethinyl estradiol (oral contraceptive)
  • Etoposide
  • Hepatitis C antivirals
  • Indinavir
  • Metoclopramide
  • Pyrimethamine
  • Rifamycin
  • Ritonavir
  • Tetracycline
  • Typhoid vaccine
  • Warfarin


Tell your doctor if you have a history of liver or kidney problems. Your labs should be monitored before treatment with MALARONE.

MALARONE may be less effective in obese patients (>100 kg).

Tell your doctor if you experience vomiting or diarrhea after taking MALARONE.

Side Effects

Common MALARONE side effects may include:

  • Abdominal pain
  • Angioedema
  • Anorexia
  • Diarrhea
  • Dizziness
  • Pruritus
  • Hallucination
  • Headache
  • Increased liver enzymes
  • Nausea
  • Neutropenia
  • Urticaria
  • Vomiting
  • Weakness


Malarone [package insert]. Research Park Triangle, NC: GlaxoSmithKline; 2008.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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