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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Luxturna (voretigene neparvovec-rzyl) is a gene therapy indicated for the treatment of patients with confirmed biallelic RPE65 mutation-associated retinal dystrophy who have sufficient viable retinal cells. It is the first FDA-approved in vivo gene therapy for a genetic disease, designed to deliver a functional copy of the RPE65 gene directly to retinal cells via subretinal injection. By restoring RPE65 enzyme activity, Luxturna enables the visual cycle to resume, improving visual function and potentially slowing further vision loss. The therapy is used in pediatric and adult patients with inherited retinal diseases leading to progressive vision loss and, in many cases, blindness.
| Fact Table | |
| Formula | Not applicable (gene therapy vector) |
| License | US FDA (2017) |
| Bioavailability | Not applicable (localized ocular delivery) |
| Legal status | Prescription only |
| Chemical Name | Voretigene Neparvovec-rzyl |
| Elimination half-life | Not formally determined (non-systemic therapy) |
| Dosage (Strength) | 1.5 × 10¹¹ vector genomes/0.3 mL per eye |
| Pregnancy | Use only if clearly needed – no human data |
| Brands | Luxturna |
| Protein binding | Not applicable |
| PubChem CID | 119531215 |
| MedlinePlus | a619047 |
| ChEBI | N/A |
| ATC code | S01XA27 |
| DrugBank | DB13919 |
| KEGG | D11030 |
| Routes of administration | Subretinal injection |
Luxturna is administered as a one-time subretinal injection to each eye, separated by at least 6 days between treatments. The recommended dose is 1.5 × 10¹¹ vector genomes per eye, administered by a retinal surgeon in a specialized surgical center. Patients should receive systemic corticosteroids (e.g., oral prednisone 1 mg/kg/day, up to 40 mg/day) for 7 days before and for 10 days after the injection, followed by tapering over the next 10 days. Proper diagnosis via genetic testing to confirm biallelic RPE65 mutations is required before treatment.
Each 1.5 mL vial of Luxturna contains:
Luxturna is a preservative-free product and must be stored at =–65°C until use. Thaw and prepare under sterile conditions immediately before administration.
Luxturna is contraindicated in patients with:
Careful assessment of retinal structure via optical coherence tomography (OCT) is required to determine retinal viability. Use of Luxturna in patients with advanced retinal degeneration may not be beneficial. Subretinal administration carries surgical risks including retinal tears, detachment, or macular holes. Patients should be advised to avoid air travel or high-altitude exposure until intraocular air bubbles resolve. There is a theoretical risk of vector shedding; contact precautions are advised for bodily fluids for a short period following treatment. Use in pregnancy has not been studied; contraception is recommended for females of reproductive potential.
Common and potential side effects include:
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