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Lupron (Leuprolide) Depot

Also Known as Lucrin,Lucrin

Prescription medicineOnly Available By Prescription

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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Lupron Depot is a prescription medication for endometriosis in women and may also be prescribed to reduce the size of uterine fibroids. In rarer instances, it may also be used as a palliative treatment for advanced prostate cancer in men. Leuprolide Acetate, a GnRH agonist drug, blocks the production of hormones in the body. These hormones are necessary for the growth of cells that contribute to endometriosis or uterine fibroids. For prostate cancer treatment, Lupron Depot inhibits testosterone production. Buy Lupron Depot from Canada Drugs Direct to get the best price.

Fact Table






4% to 18%

Legal status


Chemical Name


Elimination half-life

3 hours

Dosage (Strength)

3.75mg, 7.5mg, 11.25mg, 22.5mg, 30mg


Consult a healthcare provider for advice


Lupron Depot

Protein binding

43% and 49%

PubChem CID





Not Assigned

ATC code






Routes of administration

implant, subcutaneous, intramuscular


Lupron Depot injections should only be administered by a doctor in a medical office environment. The Lupron Depot 3-month dosing schedule is applicable only for endometriosis treatment or limiting the growth of uterine fibroids.

Endometriosis/Uterine fibroids: Injection given every 3 months, or 1x monthly based on the doctor's determination.

Advanced prostate cancer treatment: Injection given at 1, 3, 4, or 6-month intervals based on the treatment regimen requirements established by the doctor.


The active ingredient in Lupron Depot is Leuprolide Acetate.


Inform your doctor of any history of heart disease, poor cardiac health, or osteoporosis (bone density loss) before beginning treatment with Lupron Depot.

Use of Lupron Depot may decrease fertility in both men and women.

It is recommended to drink alcohol only in moderation or not at all while using Lupron Depot.

Be aware of the medication's expiry date.


Drug interaction risks are possible between Lupron Depot and other prescription medications, including albuterol, amlodipine, atorvastatin, bupropion, bicalutamide, clonazepam, cyclobenzaprine, furosemide, gabapentin, hydrochlorothiazide, levothyroxine, lisinopril, losartan, metformin, omeprazole, ondansetron, oxycodone, pantoprazole, prednisone, tamsulosin, tramadol, trazodone, and abiraterone.

Inform your doctor of all medications you are currently taking before getting a prescription and proceeding to buy Lupron Depot online.

Side Effects

Side effects of Lupron Depot are possible, and some users may experience acne, abdominal pain, diarrhea, loss of sex drive, breast tenderness, headache, hot flashes, increased sweating, injection site reactions, mood changes, rash, or weight gain. If side effects are experienced, it may be best to stop use and talk to a doctor again about alternative medications for endometriosis treatment.

Frequently Asked Questions about Lupron Depot (Leuprolide Acetate)

What is Lupron Depot?

Lupron Depot is a long-acting injectable form of leuprolide acetate, which is used to treat prostate cancer, endometriosis, and precocious puberty.

How does Lupron Depot work?

Lupron Depot works by decreasing the production of sex hormones like testosterone and estrogen. This helps slow the growth and spread of certain cancers that need sex hormones to grow.

How is Lupron Depot administered?

Lupron Depot is given as an injection under the skin, usually in the upper arm, abdomen, or buttocks. The injections are given by a healthcare provider.

What is the dosage of Lupron Depot?

The dosage of Lupron Depot depends on the condition being treated. For prostate cancer, it is typically 7.5 mg every month. For endometriosis, it is 3.75 mg monthly.

What are the side effects of Lupron Depot?

Common side effects include hot flashes, headache, depression, joint pain, and decreased libido. In men, erectile dysfunction and enlarged breasts may occur.

Does Lupron Depot interact with any medications?

Lupron Depot can interact with medications that stimulate the pituitary gland. Patients should tell their doctor about all medications they are taking.

Can I get pregnant while taking Lupron Depot?

No, Lupron Depot causes infertility in both men and women while being taken. Use non-hormonal birth control to prevent pregnancy.

How long is treatment with Lupron Depot?

Treatment often lasts from 3 to 6 months but can be longer. Your doctor will determine the appropriate length of therapy.

What monitoring is needed with Lupron Depot?

Patients will need periodic blood tests, bone density scans, and possibly CT scans to monitor cancer status and watch for side effects.

How is Lupron Depot supplied?

Lupron Depot comes in prefilled dual-chamber syringes containing powder and liquid that are mixed prior to injection. It is stored refrigerated.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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