Lumakras (Sotorasib)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Your oncologist may prescribe Lumakras for treating certain types of non-small cell lung cancer (NSCLC). Lumakras is indicated to treat locally advanced or metastatic NSCLC with a specific genetic mutation called KRAS G12C.

Lumakras works by inhibiting KRAS G12C, a mutated protein that promotes the growth of cancer cells. Before using Lumakras, your doctor will perform a genetic test to determine if you have the KRAS G12C mutation.

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Elimination half-life

5 hours

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Consult Doctor



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Routes of administration

By mouth


The usual dosage of Lumakras is 960 mg (eight tablets) by mouth once daily, with or without food.

Do not crush, chew, or break Lumakras tablets. Swallow them whole with water.


The active ingredient in Lumakras is Sotorasib.


Common drug interactions can occur with the following:

  • Abemaciclib
  • Antihepaciviral Combination Products
  • Asunaprevir
  • Avacopan
  • Avanafil
  • Avapritinib
  • Axitinib
  • Bedaquiline
  • Elacestrant
  • Elbasvir and Grazoprevir
  • Encorafenib
  • Entrectinib
  • Fedratinib
  • Fexinidazole
  • Finerenone
  • Flibanserin
  • Ganaxolone
  • Lumateperone
  • Lurbinectedin
  • Mavacamten
  • Mobocertinib
  • Neratinib
  • Nirmatrelvir and ritonavir
  • Lovastatin
  • Simeprevir
  • Sonidegib
  • Tazemetostat
  • Topotecan


Tell your doctor if you have a history of liver or kidney disease. Your oncologist will need to increase monitoring for liver problems during the first three months of treatment.

Lumakras may interact with other medications, including certain antibiotics and antifungals. It is important to inform your oncologist of all your medications before starting treatment with Lumakras.

Your oncologist should monitor for new or worsening pulmonary systems and consider stopping Lumakras if these symptoms develop.

Side Effects

Common adverse reactions may include:

  • Edema
  • Skin rash
  • Decreased serum albumin
  • Decreased serum calcium
  • Decreased serum sodium
  • Abdominal pain
  • Decreased appetite
  • Diarrhea
  • Nausea
  • Vomiting
  • Increase in urinary protein
  • Decreased hemoglobin
  • Lymphocytopenia
  • Prolonged partial thromboplastin time
  • Hepatotoxicity
  • Increased serum alanine aminotransferase
  • Increased serum alkaline phosphatase
  • Increased serum aspartate aminotransferase
  • Fatigue
  • Arthralgia
  • Musculoskeletal pain
  • Cough
  • Dyspnea
  • Pneumonia
  • Cardiac failure
  • Gastric ulcer
  • Interstitial pulmonary disease
  • Pneumonitis
  • Respiratory failure


  1. Lumakras [package insert]. Thousand Oaks, CA: Amgen; 2021.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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