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Ludiomil (Maprotiline)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Ludiomil is a prescription medication used to treat major depressive disorder (MDD), dysthymic disorder, and anxiety associated with depression. It belongs to a class of drugs known as tetracyclic antidepressants, which affect the levels of certain brain chemicals responsible for mood regulation.

Ludiomil works by increasing the amount of norepinephrine, a neurotransmitter that plays a role in mood and emotions. By enhancing norepinephrine's activity, Ludiomil helps alleviate depressive symptoms and improve overall well-being.

Fact Table







Legal status


Chemical Name


Elimination half-life

27–58 hours

Dosage (Strength)

25mg, 75mg


Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


The starting dosage is 25-75 mg by mouth once daily or in divided doses. After two weeks, the dose can be increased by 25 mg. The usual effective dose range is 150-225 mg.


The active ingredient in Ludiomil is maprotiline.


Common drug-drug interactions may include:

  • Acetylcholinesterase Inhibitors
  • Aclidinium
  • Alcohol
  • Alizapride
  • Amantadine
  • Anticholinergic Agents
  • Azelastine (Nasal)
  • Blonanserin
  • Botulinum Toxin-Containing Products
  • Brexanolone
  • Brimonidine (Topical)
  • Bromopride
  • Bromperidol
  • Buprenorphine
  • Cannabinoid-Containing Products
  • Chloral Betaine
  • Chlormethiazole
  • Chlorphenesin Carbamate
  • Cimetropium
  • CloZAPine
  • CNS Depressants
  • Daridorexant
  • DexmedeTOMIDine
  • Difelikefalin
  • Dimethindene (Topical)
  • Doxylamine
  • DroPERidol
  • Eluxadoline
  • Esketamine
  • Flunarizine
  • Flunitrazepam
  • Gastrointestinal Agents
  • Glucagon
  • Glycopyrrolate
  • Glycopyrronium (Topical)
  • HydrOXYzine
  • Ipratropium
  • Itopride
  • Ixabepilone
  • Kava Kava
  • Kratom
  • Lemborexant
  • Levosulpiride
  • Levothyroxine
  • Lisuride
  • Lofexidine
  • Magnesium Sulfate
  • Methotrimeprazine
  • Metoclopramide
  • MetyroSINE
  • Mianserin
  • Minocycline
  • Mirabegron
  • Monoamine Oxidase Inhibitors
  • Nitroglycerin
  • Olopatadine
  • Opioid Agonists
  • Orphenadrine
  • Oxatomide
  • Oxomemazine
  • Oxybate Salt Products
  • Paraldehyde
  • Perampanel
  • Piribedil
  • Potassium Chloride
  • Potassium Citrate
  • Pramipexole
  • Pramlintide
  • Procarbazine
  • Ramosetron
  • Revefenacin
  • Ropeginterferon Alfa-2b
  • ROPINIRole
  • Rotigotine
  • Rufinamide
  • Secretin


Do not use Ludiomil if you have a history of seizures, heart problems, liver or kidney disease, or urinary retention.

Ludiomil may cause drowsiness or dizziness. Avoid activities that require alertness until the response to Ludiomil is known.

Side Effects

Common side effects may include:

  • Anemia
  • Bronchitis
  • Cardiac failure
  • Cough
  • Decreased hemoglobin
  • Decreased hematocrit
  • Dizziness
  • Dyspepsia
  • Fatigue
  • Flushing
  • Fluid retention
  • Headache
  • Hypersensitivity
  • Hypotension
  • Increased liver enzymes
  • Nasal congestion
  • Nausea
  • Oligospermia
  • Peripheral edema
  • Sinusitis
  • Vomiting
  • Weakness


Ludiomil [package insert]. Morgantown, WV: Mylan; 2014.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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