Lokelma (Sodium Zirconium Cyclosilicate)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Lokelma is available by prescription only to lower potassium levels in the blood.

Because Lokelma does not start working right away, it should not be used to lower emergent and life-threatening potassium levels.

Lokelma is available as an oral suspension of 5 grams per packet or 10 grams per packet.


Take Lokelma exactly as your doctor has prescribed. Tell your doctor or pharmacist about any questions or concerns you have about the medication.

Patients are recommended to start taking 10 grams by mouth three times a day for up to 2 days. 10 grams are recommended to be taken daily for continued treatment. The dose may be adjusted by the doctor as needed until potassium levels are within goal range.

Chronic hemodialysis patients may require a lower dose.


A potassium binder, sodium zirconium cyclosilicate, is the active ingredient in Lokelma.


According to the most recent Lokelma Prescribing Information, there are no contraindications to the medication.


  • Before you start taking Lokelma, tell your doctor about:
    • All the medications you take, including herbals, vitamins, and supplements.
    • Your allergies.
    • Your current health problems and past medical history.
    • Your pregnancy or breastfeeding status.
  • Lokelma should not be administered to patients with severe constipation, bowel obstruction or impaction, or any other gastrointestinal motility problem.
  • Some patients may experience swelling due to the fact that Lokelma contains sodium. Signs and symptoms of swelling should be monitored, especially in patients who are on a low-sodium diet or have heart failure or kidney disease.
  • Hemodialysis patients may develop low potassium levels in the blood with Lokelma treatment.
  • Lokelma can look like an imaging agent during abdominal X-rays.

Side Effects

Mild to moderate swelling is the most common side effect of Lokelma; however, patients can experience other side effects. Contact your doctor right away if you have side effects that concern you or won’t go away.


  1. Lokelma (sodium zirconium cyclosilicate). Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2022.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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