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Linzess (Linaclotide)

Also Known as Constella

Prescription medicineOnly Available By Prescription

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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Linzess is a guanylate cyclase C agonist indicated in adults for the treatment of Irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC).


IBS-C - Take 290mcg orally once daily. CIC - Take 145mcg orally once daily. Take on a empty stomach, at least 30 minutes prior to the first meal of the day.




For elderly patients, although no dose adjustment is required the treatment should be carefully monitored and periodically re-assessed Linzess is contraindicated for patients with known or suspected mechanical gastrointestinal obstruction. Should prolonged (e.g. more than 1 week) or severe diarrhoea occur, medical advice should be sought and temporary discontinuation of linaclotide until diarrhoea episode is resolved may be considered.

Side Effects

Side effects which are common for Linzess include:

  • Diarrhea
  • Stomach ache or discomfort
  • Bloating
  • Gas
  • Headache
  • Sinus pain or sneezing

The side effects of Linzess are not confined to the list above; other effects can occur too. Remember that your pharmacist or doctor has mediated that the benefits of this medication are higher than the risk of side effects while recommending it to you. Consult your doctor if you experience any side effects or feel discomfort.

Frequently Asked Questions about Linzess

What does Linzess do?

Linzess helps with constipation and IBS symptoms by making stools softer and prompting bowel movements.

How to take Linzess?

Take Linzess in the morning before eating, swallowing the capsule whole.

How long does it take for Linzess to kick in?

Relief from Linzess can vary, with some feeling better within days to a week after starting.

What to avoid when taking Linzess?

Don't use Linzess with intestinal blockages, and always swallow the capsule whole.

Do you have a bowel movement every day with Linzess?

While Linzess can promote regular bowel movements, individual responses differ. Follow your doctor's advice.

Why can't you take Linzess at night?

Taking Linzess in the morning ensures it works optimally by being absorbed properly.

What is the most common side effect of Linzess?

Diarrhea is the most common side effect. If severe or prolonged, consult your doctor.

How long can you stay on Linzess?

Your doctor will advise on how long to take Linzess based on your condition.

Does Linzess cause weight gain?

Weight gain isn't typically associated with Linzess.

Can you drink alcohol with Linzess?

There are no specific alcohol restrictions, but consult your doctor for any potential interactions.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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