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Lialda (Mesalamine)

Also Known as Mezavant

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


LIALDA (mesalamine) is a medication prescribed to treat Inflammatory Bowel Disease (IBD). IBD can manifest in two different ways, including Crohn's disease (CD) and Ulcerative Colitis (UC). CD affects both the small and large intestines, while UC only affects the large intestine.

IBD is an autoimmune disease where parts of the gastrointestinal tract are abnormally inflamed. Inflammation is when cells become swollen and they recruit immune cells to the site. The inflammation process reduces the intestinal cells’ ability to absorb nutrients from food and also can cause symptoms of constipation or diarrhea.

LIALDA works by inhibiting two types of signaling molecules used by the immune system to activate inflammation, prostaglandins, and cyclooxygenases. By inhibiting these chemical signals, LIALDA helps to reduce inflammation and resolve symptoms of IBD.

Fact Table




FDA approved


Orally: 20–30% (delayed-release tablets), varies by formulation

Legal status

Prescription drug

Chemical Name


Elimination half-life

0.5–1.5 hours (mesalamine), 5–10 hours (N-acetyl-5-aminosalicylic acid)

Dosage (Strength)

Tablets (1.2 g), Suppositories (500 mg, 1 g), Enema (4 g/60 mL)

Pregnancy advice

Consult a doctor – Category B (US)


Lialda, Asacol, Pentasa, Apriso, others

Protein binding


PubChem CID






ATC code






Routes of administration

Oral, Rectal


Take LIALDA exactly as prescribed by your doctor. LIALDA generic is mesalamine, but all brands and generic versions are different. Each contains different formulations of mesalamine and are not interchangeable.

The usual LIALDA dosage is 2.4 g to 4.8 by mouth once daily with food. The usual duration of LIALDA treatment is 8 weeks but may be longer or shorter depending on your disease characteristics and needs. 


The active ingredient in LIALDA is mesalamine.


Patients who have pyloric stenosis should use caution when taking LIALDA because mesalamine may release more slowly in the colon, decreasing drug efficacy.

Tell your doctor if you have a history of cardiovascular disease, as LIALDA can lead to hypersensitivity reactions like myocarditis and pericarditis.

Speak with your doctor if you have a history of kidney (renal) issues before starting LIALDA.

Side Effects

Some of the most common side effects of LIALDA include:

  • Alopecia
  • Headache
  • Increase liver enzymes
  • Pancreatitis
  • Pruritus
  • Worsening of Ulcerative Colitis


  1. Lialda [package insert]. Wayne, PA: Shire; 2009.
  2. Mayo Clinic, Inflammatory bowel disease (IBD), March 3rd, 2020. Retrieved April 2020.

Frequently Asked Questions about Lialda (Mesalamine)

What is Lialda used for?

Lialda, also called mesalamine, helps with ulcerative colitis by calming bowel inflammation, easing symptoms like diarrhea and belly pain.

What happens if you take Lialda without food?

You can take Lialda with or without food. But taking it with food might lessen strong side effects.

Is Lialda a steroid?

No, Lialda isn’t a steroid. It’s in a group of drugs called aminosalicylates.

How long does it take for Lialda to work?

It could take days or weeks before Lialda eases ulcerative colitis symptoms, like belly pain.

Why is Lialda so expensive?

Lialda’s cost comes from years of research to ensure it's safe and effective, which can make it pricey.

Does Lialda cause weight loss?

Lialda itself doesn’t cause weight loss, but it treats ulcerative colitis, which can lead to weight changes.

Is Lialda safe for long-term use?

Yes, Lialda is often used long-term if it’s safe and helpful for you and your doctor agrees.

How long should you take Lialda?

Lialda is meant for long-term use if it works well and is safe for you, as decided by you and your doctor.

Can mesalamine cause extreme fatigue?

There’s no clear info on whether mesalamine, in Lialda, can cause extreme fatigue. Best ask a healthcare provider.

Does Lialda cause anxiety?

Anxiety is a rare side effect of Lialda.

What to avoid when taking mesalamine?

The things to avoid can vary depending on your health. Talk to your healthcare provider about it.

Can you drink alcohol while taking Lialda?

It’s not clear if there’s an issue with Lialda and alcohol. Consult your healthcare provider.

What is the most common side effect of mesalamine?

Common side effects of mesalamine include headache, gas, and abdominal pain.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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