Only Available By Prescription
Top Generic choice
| Strength | Pack Size | Qty | |
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Strength
50mg
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Lamprene (clofazimine) is an oral antimycobacterial agent indicated primarily for the treatment of lepromatous leprosy and multibacillary Hansen’s disease, in combination with other antileprosy drugs such as dapsone and rifampin. Clofazimine has anti-inflammatory and bactericidal activity against Mycobacterium leprae, and is particularly effective in preventing and managing erythema nodosum leprosum (ENL), a severe immunologic complication of leprosy. It also exhibits activity against certain nontuberculous mycobacteria (NTM), such as Mycobacterium avium complex (MAC), although this use is off-label.
| Fact Table | |
| Formula | C27H22Cl2N4 |
| License | US FDA (Orphan Drug); WHO List of Essential Medicines |
| Bioavailability | Variable; improved with fatty meal (45–70%) |
| Legal status | Prescription only; restricted distribution in some countries |
| Chemical Name | N,5-bis(4-chlorophenyl)-3-(1-methylethylimino)-3-phenazinamine |
| Elimination half-life | ~70 days |
| Dosage (Strength) | 50 mg and 100 mg oral capsules |
| Pregnancy | Category C – use only if benefits outweigh risks |
| Brands | Lamprene, generic clofazimine (limited availability) |
| Protein binding | ~90% |
| PubChem CID | 2794 |
| MedlinePlus | a682279 |
| ChEBI | CHEBI:3765 |
| ATC code | J04BA01 |
| DrugBank | DB00845 |
| KEGG | D00299 |
| Routes of administration | Oral |
Clofazimine should be used under the supervision of a physician experienced in the treatment of leprosy.
Treatment duration often extends 6–12 months or longer, depending on the regimen and clinical response.
Each soft gelatin capsule of Lamprene contains:
Inactive ingredients may include:
Lamprene capsules are typically red or reddish-brown, and lipid-soluble, accumulating in fatty tissues.
Lamprene is contraindicated in patients with:
Long-term use of clofazimine may lead to crystal deposition in intestinal tissues, potentially resulting in chronic abdominal pain, diarrhea, or intestinal obstruction. Caution is advised in patients with pre-existing GI disease. Clofazimine causes skin and body fluid discoloration (ranging from pink to dark brown), which may be distressing to patients but is reversible after discontinuation. Monitor liver and renal function during prolonged therapy. Use with caution in patients on QT-prolonging agents or with cardiac history, as clofazimine may prolong the QT interval. Not recommended in pediatric patients unless no alternatives are available.
Common and potential side effects include:
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