Kynmobi (Apomorphine HCI) Sublingual film

Description

Kynmobi (apomorphine hydrochloride) is a dissolvable film that is placed under the tongue for the treatment of short-term, intermittent “off” episodes in patients who have Parkinson's Disease.

Directions

Follow your prescription's instructions. Talk to your doctor or pharmacist about any questions or concerns you may have about your Kynmobi prescription. Your doctor may prescribe a medication to help prevent nausea and vomiting associated with Kynmobi treatment.

Kynmobi is available in 10 mg, 15 mg, 20 mg, 25 mg, and 30 mg sublingual films. 

The Kynmobi film should be placed under the tongue to dissolve. Do not cut, chew, or swallow the films. 

The general dose is between 10 mg and 30 mg per dose as needed. You should wait at least 2 hours between doses before administering another dose. Do not take more than 5 doses a day. Do not take more than 30 mg at one time.

Ingredients

The active ingredient contained in Kynmobi is apomorphine hydrochloride, a non-ergoline dopamine agonist.

Contraindications

Avoid taking Kynmobi with 5HT3 antagonists such as ondansetron, granisetron, dolasetron, palonosetron, and alosetron. If you do not know whether or not you take 5HT3 antagonists, ask your doctor. 

Avoid taking Kynmobi if you have an allergy to apomorphine, sodium metabisulfite, or any of Kynmobi's other ingredients or excipients.

Cautions

• Before you start treatment with Kynmobi, inform your doctor:
• Of all the medications you take, including prescription, over-the-counter, vitamins, and herbal supplements
• Of your allergies
• Of your medical conditions
• Of your alcohol consumption
• If you are pregnant or plan to become pregnant
• If you are breastfeeding or plan to breastfeed 
• Nausea and vomiting can occur with the use of Kynmobi.
• Drowsiness or falling asleep, even during the daytime, can occur with the use of Kynmobi. Avoid driving and operating machinery until you know how you are affected by the medication.
• Low blood pressure can occur with the use of Kynmobi. Be sure to monitor your blood pressure during treatment with Kynmobi.
• Irritation to the inside of your mouth can occur with the use of Kynmobi. If this occurs, let your doctor know as he or she may pause or stop your treatment.
• Your risk for falls may be greater with the use of Kynmobi.
• Hallucinations and psychosis can occur with the use of Kynmobi. Immediately contact your doctor if you experience these effects.
• Impulsive behaviors can occur with the use of Kynmobi. Immediately contact your doctor if you develop impulsive behaviors or intense urges to gamble, spend money, or other urges.
• Withdrawal-emergent and confusion with symptoms such as fever, muscle stiffness, altered mental status, autonomic instability, and increased serum creatine kinase levels can occur if Kynmobi is suddenly discontinued or the dose is suddenly decreased. Withdrawal should be gradual and doses should be tapered. 
• QTc prolongation that can lead to torsades de pointes or death can occur with the use of Kynmobi. Discuss risk factors with your doctor before starting treatment with Kynmobi.

Side Effects

Dizziness, drowsiness, nausea, and mouth irritation, pain, and tingling are the most common side effects of Kynmobi. However, other side effects can occur with Kynmobi. Immediately call your doctor if you have side effects that bother you or continue.

Reference:

Kynmobi (apomorphine hydrochloride) sublingual film. Marlborough, MA: Sunovion Pharmaceuticals Inc.; 2020.

About Dr. Savannah Muncy (Page Author)

Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....