Only Available By Prescription
Top brand choice
| Strength | Pack Size | Qty | |
|---|---|---|---|
|
Strength
150mg
|
We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Kalydeco (ivacaftor) is a CFTR potentiator indicated for the treatment of cystic fibrosis (CF) in patients aged 1 month and older who have at least one mutation in the CFTR gene that is responsive to ivacaftor based on clinical and/or in vitro assay data. Ivacaftor enhances the function of the defective CFTR protein at the cell surface by increasing chloride transport across epithelial cells, thereby improving pulmonary function, weight gain, and reducing pulmonary exacerbations. Kalydeco was the first disease-modifying therapy approved for CF targeting the underlying genetic defect rather than just symptoms.
| Fact Table | |
| Formula | C24H28N2O3 |
| License | US FDA (2012); EMA |
| Bioavailability | ~35% (increases with high-fat meal) |
| Legal status | Prescription only |
| Chemical Name | N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide |
| Elimination half-life | ~12 hours |
| Dosage (Strength) | 150 mg tablets (taken every 12 hours with fat-containing food) |
| Pregnancy | Category B – no evidence of risk in humans, but limited data |
| Brands | Kalydeco (Vertex Pharmaceuticals) |
| Protein binding | ~99% |
| PubChem CID | 16220172 |
| MedlinePlus | a612024 |
| ChEBI | CHEBI:68528 |
| ATC code | R07AX02 |
| DrugBank | DB08820 |
| KEGG | D09738 |
| Routes of administration | Oral |
Kalydeco is administered orally, and the dose varies by age and weight:
Tablets must be swallowed whole and not chewed or crushed. Administer with fat-containing meals to enhance absorption (e.g., whole milk, cheese, eggs, avocado). Dose adjustment is required in patients with moderate or severe hepatic impairment and when co-administered with CYP3A inhibitors.
Each film-coated tablet contains:
Inactive ingredients include:
Kalydeco is contraindicated in:
Monitor liver function tests (LFTs) prior to initiation and periodically thereafter due to the risk of elevated transaminases. Use caution in patients with hepatic or renal impairment. Cataracts have been reported in pediatric patients; baseline and follow-up ophthalmologic exams are recommended. Avoid use with strong CYP3A inducers (e.g., rifampin, carbamazepine), which may reduce ivacaftor exposure. Dose reduction is required with strong CYP3A inhibitors (e.g., ketoconazole). Not approved for patients with non-responsive CFTR mutations.
Common and potential side effects include:
Exceptional Customer Service
We pride ourselves on delivering excellent customer service with as much accessibility as possible.
If you have any questions at all, or would like to place an order, you are encouraged to contact us by toll-free
phone 1-888-904-8467 or email info@canadadrugsdirect.com.
Top Safety and Quality
Canada Drugs Direct employs dedicated, professional licensed pharmacists to ensure that each and every order is reviewed before it is dispensed for the safety and health of our customers. At CanadaDrugsDirect.com, your health is our top priority.
Product Reviews