Kaletra (Ritonavir/Lopinavir)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


If you have human immunodeficiency virus (HIV-1) infection, your doctor may prescribe the medication Kaletra.

Kaletra is often used in combination with other antivirals to stop the replication of HIV and slow down the progression of the disease.

Fact Table







Legal status

RX Only

Chemical Name


Elimination half-life

3-5 hours

Dosage (Strength)



No known risks


Kaletra, Aluvia

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


Kaletra comes in the strength 800/200 mg and is given either once or twice daily.

The tablets can be taken with or without food and must be swallowed whole without crushing or chewing them.


The active ingredients in Kaletra are lopinavir and ritonavir.


Kaletra contains ritonavir, which causes an intentional drug interaction that increases lopinavir levels in the body. For this reason, there are many drug interactions with Kaletra. Some examples include:

  • Alfuzosin
  • Alprazolam
  • Amiodarone
  • Antihepaciviral combination products
  • Apalutamide
  • Aprepitant
  • Atovaquone
  • Avanafil
  • Bortezomib
  • Bosutinib
  • Budesonide
  • Clarithromycin
  • Clobetasone
  • Cobicistat
  • Darunavir
  • Disulfiram
  • Domperidone
  • Doxorubicin
  • Dronedarone
  • Eletriptan
  • Eplerenone
  • Ergot derivatives
  • Everolimus
  • Flecainide
  • Fluticasone
  • Fosamprenavir
  • Fosaprepitant
  • Ibrutinib
  • Ivabradine
  • Lovastatin
  • Lurasidone
  • Metronidazole
  • Midazolam
  • Pimozide
  • Propafenone
  • Quinidine
  • Quinine
  • Red yeast rice
  • Rifampin
  • Rivaroxaban
  • Salmeterol
  • Simvastatin
  • St. John's Wort
  • Tamsulosin
  • Triazolam
  • Vincristine
  • Voriconazole


Tell your doctor if you have a history of kidney or liver problems before starting Kaletra.

Your doctor should screen for heart disease and arrhythmias before you start taking this medication.

Use caution if you have ever had pancreatitis.

Kaletra can affect the levels of blood glucose and cholesterol.

Side Effects

Kaletra side effects may include:

  • Abdominal pain
  • Altered glucose
  • Anemia
  • Anxiety
  • Decreased creatinine clearance
  • Dermatitis
  • Diarrhea
  • Dizziness
  • Erectile dysfunction
  • Hypertension
  • Increased liver enzymes
  • Leukopenia
  • Lower respiratory tract infection
  • Neutropenia
  • Upper respiratory tract infection
  • Vomiting


  1. Kaletra [package insert]. Chicago, IL: AbbVie; 2016.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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