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Januvia (Sitagliptin Phosphate)

Also Known as Istavel

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


JANUVIA belongs to a new breakthrough class of prescription medications called dipeptidyl peptidase-4 (DPP-4) inhibitors that improves blood sugar control in patients with type 2 diabetes. JANUVIA enhances a natural body system called the incretin system, which helps to regulate glucose by affecting the beta cells and alpha cells in the pancreas. Through DPP-4 inhibition, JANUVIA works only when blood sugar is elevated to address diminished insulin due to beta-cell dysfunction and uncontrolled production of glucose by the liver due to alpha-cell and beta-cell dysfunction.

JANUVIA is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. It is important to use this medication regularly to get the most benefit.

Fact Table







Legal status

RX Only

Chemical Name

Sitagliptin Phosphate

Elimination half-life

8-14 hours

Dosage (Strength)

25mg (28 or 84 tablets), 50mg (28 or 84 tablets), 100mg (28 or 84 tablets)


Consult a doctor



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth (tablets)


Take JANUVIA as exactly as prescribed by your doctor. Your doctor may occasionally change your dose to make sure you get the best results. Patients can take JANUVIA with or without food.

Ask your doctor how to adjust your JANUVIA dose if needed. Do not change your medication dose or schedule without your doctor's advice.


JANUVIA is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. Before taking JANUVIA, tell your doctor if you have:

  • kidney disease
  • are on dialysis
  • have a history of pancreatitis
  • are pregnant or planning on becoming pregnant
  • breastfeeding a newborn
  • are allergic to JANUVIA
  • are in a state of diabetic ketoacidosis

Patients may have to visit their doctor regularly to check their blood sugar checked often. It is important to know the signs of low blood sugar (hypoglycemia) and how to recognize them. Common signs and symptoms of low blood sugar include: headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating.

JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA.

Talk with your doctor about additional risks and benefits of using JANUVIA.

Side Effects

Serious side effects can occur in patients taking JANUVIA, including inflammation of the pancreas (pancreatitis) which may be severe and lead to death or serious allergic reactions. Contact your doctor immediately.

The most common side effects of JANUVIA include:

  • upper respiratory infection
  • stuffy or runny nose and sore throat
  • headache

JANUVIA may have other side effects, including:

  • stomach upset and diarrhea
  • swelling of the hands or legs, when JANUVIA is used with the combination of metformin & rosiglitazone (other types of diabetes medicines)
  • elevated liver enzymes

Patient must ensure they do not allow their blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about additional side effects or any side effect that bothers you or that do not go away.

Frequently Asked Questions about Januvia (Sitagliptin)

What are the bad side effects of Januvia?

Serious effects may include pancreatitis, heart issues, kidney problems, allergic reactions, severe joint pain, and bullous pemphigoid.

What is the most common side effect of sitagliptin?

Typical side effects of Januvia consist of upper respiratory infections, nasal congestion, and sore throat.

What is the major side effect of Januvia?

The significant risks associated with Januvia are pancreatitis, heart problems, and kidney issues.

Is Januvia bad for your kidneys?

Januvia has been linked to kidney problems, sometimes necessitating dialysis. If you have kidney concerns, talk to your doctor before starting Januvia.

Does Januvia cause weight gain?

Weight gain isn't commonly linked to Januvia, though individual responses may differ.

How long can you take Januvia?

The duration of Januvia usage depends on your health condition and your doctor’s advice. Always follow their guidance.

Can Januvia be stopped abruptly?

Consult your doctor before stopping Januvia suddenly. Abrupt discontinuation of any medication can have consequences. Your doctor will advise you on the proper approach.

Is it better to take Januvia in the morning or at night?

Januvia is typically taken once daily, with timing varying between morning and night. Follow your doctor’s instructions for optimal results.

What to avoid while taking Januvia?

While on Januvia, limit alcohol intake. Otherwise, there are no specific dietary restrictions. Always heed your doctor’s advice.

Is metformin and Januvia the same?

No, they work differently. Metformin improves insulin function and lowers liver glucose production, while Januvia boosts insulin release and reduces blood sugar as a DPP-4 inhibitor.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for your pet. See your veterinarian for medical advice and treatment for your pet if you have any concerns.

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