Janumet (Sitagliptin / Metformin)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


This medicine is a dipeptidyl peptidase-4 enzyme inhibitor and biguanide antidiabetic combination used along with a diet and exercise program to control high blood sugar in certain patients with type 2 diabetes.

Fact Table


Sitagliptin: C16H15F6N5O; Metformin: C4H11N5


FDA approved


Sitagliptin: ~87%; Metformin: 50-60%

Legal status

Prescription medicine

Chemical Name

Sitagliptin: 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine; Metformin: N,N-dimethylimidodicarbonimidic diamide

Elimination half-life

Sitagliptin: ~12.4 hours; Metformin: ~6.2 hours

Dosage (Strength)

Available in combinations of 50mg Sitagliptin/500mg Metformin, 50mg Sitagliptin/1000mg Metformin, and others

Pregnancy advice

Use only if clearly needed and the potential benefits outweigh the risks. Consult a healthcare provider.



Protein binding

Sitagliptin: 38%; Metformin: Not significant

PubChem CID

Sitagliptin: 4369359; Metformin: 4091




Sitagliptin: CHEBI:40237; Metformin: CHEBI:6801

ATC code



Sitagliptin: DB01261; Metformin: DB00331


Sitagliptin: D08514; Metformin: D04966

Routes of administration



Follow the directions for using this medicine provided by your doctor. This medicine may come with a patient information leaflet. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. TAKE THIS MEDICINE with food. DRINK PLENTY OF FLUIDS while taking this medicine. STORE THIS MEDICINE at room temperature between 68 and 77 degrees F (20 and 25 degrees C), in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Take this medicine regularly to receive the most benefit from it. Taking this medicine at the same times each day will help you to remember. CONTINUE TO TAKE THIS MEDICINE even if you feel well. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.


SIDE EFFECTS that may occur while taking this medicine include diarrhea, gas, headache, indigestion, nausea, sore throat, stomach pain or upset, stuffy or runny nose, vomiting, or weakness. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience chest pain or discomfort; dizziness or lightheadedness; fast or difficult breathing; fever, chills, or persistent sore throat; feeling of being unusually cold; general feeling of being unwell; muscle pain or weakness; red, blistered, swollen, or peeling skin; slow or irregular heartbeat; swelling of your hands, legs, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; unusual hoarseness; unusual or persistent stomach pain or discomfort; unusual drowsiness; or unusual tiredness or weakness. An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Side Effects

Some common side effects that you may experience with Janumet medication are:

  • Diarrhoea
  • Gas
  • Headache
  • Indigestion
  • Nausea
  • Sore throat
  • Stomach pain
  • Upset stomach
  • Stuffy or runny nose
  • Vomiting
  • Weakness
Serious side effects from this drug are very rare; however, if you experience any of the following side effects, notify your doctor immediately:
  • Chest pain or discomfort
  • Dizziness
  • Lightheadedness
  • Fast or difficult breathing
  • Fever
  • Chills
  • Sore throat
  • Feeling of being unusually cold
  • General feeling of being unwell
  • Muscle pain or weakness
  • Slow or irregular heartbeat
  • Swelling of your hands, legs, face, lips, eyes, throat, or tongue
  • Difficulty swallowing or breathing
  • Unusual hoarseness
  • Unusual or persistent stomach pain or discomfort
  • Unusual drowsiness
  • Unusual tiredness or weakness
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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