Also Known as Jakavi

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Jakafi is a medication prescribed for the treatment of certain blood disorders. It belongs to a class of drugs called Janus kinase (JAK) inhibitors, which block specific enzymes involved in the growth and survival of abnormal blood cells.

Jakafi is primarily used to treat myelofibrosis (a rare type of bone marrow disorder), and polycythemia vera, a condition characterized by an overproduction of red blood cells. It helps to reduce symptoms such as enlarged spleen, fatigue, and itching and may also improve the overall quality of life for individuals affected by these conditions.

Fact Table







Legal status


Chemical Name


Elimination half-life

2.8-3 hours

Dosage (Strength)

5mg, 15mg, 20mg


Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


Your healthcare team will determine the correct dose of Jakafi. Take it exactly as prescribed, and do not change the dosage without speaking with your physician.

Jakafi can be taken with or without food.


The active ingredient in Jakafi is Ruxolitinib.


Common drug-drug interactions may include:

  • 5-Aminosalicylic Acid Derivatives
  • Abrocitinib
  • Antithymocyte Globulin (Equine)
  • Azithromycin
  • Baricitinib
  • BCG Products
  • Brincidofovir
  • Brivudine
  • Chloramphenicol (Ophthalmic)
  • Cladribine
  • Clofazimine
  • CloZAPine
  • Coccidioides immitis Skin Test
  • COVID-19 Vaccine
  • Deferiprone
  • Dengue Tetravalent Vaccine (Live)
  • Denosumab
  • Deucravacitinib
  • Dipyrone
  • Fexinidazole
  • Filgotinib
  • Fluconazole
  • Fusidic Acid
  • Inebilizumab
  • Influenza Virus Vaccines
  • Leflunomide
  • Mumps- Rubella- or Varicella-Containing Live Vaccines
  • Nadofaragene Firadenovec
  • Natalizumab
  • Ocrelizumab
  • Ofatumumab
  • Olaparib
  • Pidotimod
  • Pimecrolimus
  • Pneumococcal Vaccines
  • Poliovirus Vaccine
  • Polymethylmethacrylate
  • Promazine
  • Rabies Vaccine
  • Ropeginterferon Alfa-2b
  • Sipuleucel-T
  • Sphingosine 1-Phosphate (S1P) Receptor Modulator
  • Tacrolimus (Topical)
  • Talimogene Laherparepvec
  • Tertomotide
  • Tofacitinib
  • Typhoid Vaccine
  • Ublituximab
  • Upadacitinib\


Your doctor should perform routine skin examinations while you take Jakafi.

Tell your doctor if you have a history of heart problems.

Ask your doctor and pharmacist about the full list of precautions.

Side Effects

Common side effects may include:

  • Anemia
  • Basal cell carcinoma of the skin
  • Bruise
  • Constipation
  • Cough
  • Diarrhea
  • Dyspnea
  • Dizziness
  • Edema
  • Exacerbation of hepatitis B
  • Fatigue
  • Fever
  • Flatulence
  • Headache
  • Hemorrhage
  • Herpes simplex infection
  • Herpes zoster infection
  • Hypercholesteremia
  • Hypertriglyceridemia
  • Increased LDL cholesterol
  • Increased serum alanine aminotransferase
  • Increased serum aspartate aminotransferase
  • Infection
  • Insomnia
  • Merkel cell carcinoma
  • Muscle spasm
  • Musculoskeletal pain
  • Nausea
  • Neutropenia
  • Progressive multifocal leukoencephalopathy
  • Serious infection
  • Squamous cell carcinoma of the skin
  • Thrombocytopenia
  • Tuberculosis
  • Urinary tract infection
  • Viral infection
  • Weight gain


Jakafi [package insert]. Wilmington, DE: Incyte Corporation; 2021.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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