Ismo (Isosorbide Mononitrate)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Ismo is a prescription drug used to prevent angina, which is chest tightness caused by narrow blood vessels of the heart. Prolonged angina can deprive the heart cells of oxygen and can cause damage to heart cells.

Ismo is an organic nitrate. Once ingested, it forms nitric oxide, which can cause the relaxation of the smooth muscle of the blood vessels. Relaxing the blood vessels helps to increase blood flow.

Ismo is a nitrate medication that should be taken on a schedule. It is not an as-needed medication.

Fact Table






More than 95%

Legal status


Chemical Name

Isosorbide mononitrate

Elimination half-life

5 hours

Dosage (Strength)



Not Recommended


Monoket, Imdur

Protein binding

Less than 5%

PubChem CID






ATC code






Routes of administration

By mouth


Take Ismo medication 20 mg twice daily, approximately seven hours apart. The first dose should be taken upon waking and the second dose seven hours later. Do not take this medication 12 hours apart or using another dosing interval.

Take this medication with or without food. 


The active ingredient in Ismo medication is isosorbide dinitrate.


Tell your doctor and pharmacist if you are taking any of these medications before taking Ismo:

  • Alcohol 
  • Dapoxetine
  • Dapsone (Topical)
  • Local Anesthetics
  • Molsidomine
  • Nitric Oxide
  • Prilocaine
  • Riociguat
  • Sildenafil
  • Sodium Nitrite
  • Tadalafil
  • Vardenafil


Ismo can cause drowsiness, so use caution if operating a vehicle or heavy machinery. 

Severe hypotension (low blood pressure) can occur with this drug. Your doctor should monitor for these symptoms, especially when starting this medication. Drinking alcohol can make these effects worse.

Tell your doctor if you have a history of neurological injury like a traumatic brain injury.

Ismo is not recommended for use in patients with acute myocardial infarction or heart failure.

Side Effects

When you start taking this medication, common Ismo side effects can include:

  • Chest pain
  • Constipation
  • Diarrhea
  • Dizziness
  • Dry mouth
  • Fainting
  • Flushing
  • Headache
  • Irregular heartbeat
  • Lightheadedness
  • Orthostatic hypotension
  • Pain in joints
  • Shortness of Breath
  • Skin warmth


  1. Ismo [package insert]. Reddy; 2007.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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