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Intuniv (Guanfacine HCL)

Prescription medicineOnly Available By Prescription
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Top brand choice

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1mg
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2mg
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Strength
3mg
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Strength
4mg
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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

Top Generic choice

Strength Pack Size Qty
Strength
1mg
Pack Size
Qty
Strength
2mg
Pack Size
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Strength
3mg
Pack Size
Qty
Strength
4mg
Pack Size
Qty

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Your doctor or another healthcare provider may prescribe guanfacine to treat Attention Deficit Hyperactivity Disorder (ADHD). Intuniv is a non-stimulant medication that can be given to children and adolescents aged 6-17. It is used for patients that cannot use stimulants or that have failed stimulant medication.

Fact Table

Formula

C9H9Cl2N3O

License

US FDA, EU EMA

Bioavailability

80–100%

Legal status

Rx-only

Chemical Name

Guanfacine

Elimination half-life

10-17 hours

Dosage (Strength)

1 mg to 4 mg

Pregnancy

No Known Risk

Brands

Estulic, Intuniv

Protein binding

70%

PubChem CID

3519

MedlinePlus

a601059

ChEBI

5558

ATC code

C02AC02

DrugBank

DB01018

KEGG

D08031

Routes of administration

By mouth

Directions

The dosage of Intuniv is determined by the physician and should not be changed unless directed.

The drug is available as Intuniv 1 mg, 2 mg, 3 mg, and 4 mg tablet sizes.

Ingredients

The active ingredient is guanfacine. Guanfacine works by slowing down certain nerve signals in the brain that are responsible for behavior.

Interactions

Tell your doctor and pharmacist if you are taking any of the following before you start Intuniv.

  • Alcohol 
  • Amifostine
  • Amiodarone
  • Apalutamide
  • Aprepitant
  • Azelastine 
  • Berotralstat
  • Beta-Blockers
  • Bromperidol
  • Buprenorphine
  • Carbamazepine
  • Ceritinib
  • Cimetidine
  • Conivaptan
  • Crizotinib
  • Cyclosporine
  • Diltiazem
  • Dronedarone
  • Duvelisib
  • Enzalutamide
  • Erythromycin
  • Fedratinib
  • Fluconazole
  • Flunitrazepam
  • Fosamprenavir
  • Fosaprepitant
  • Fosnetupitant-palonosetron
  • Fosphenytoin
  • Fusidic Acid (Systemic)
  • Grapefruit juice
  • Imatinib
  • Isavuconazole
  • Lefamulin
  • Letermovir
  • Lumacaftor
  • Lumacaftor-ivacaftor
  • Mirtazapine
  • Mitotane
  • Netupitant
  • Nilotinib
  • Obinutuzumab
  • Orphenadrine
  • Oxomemazine
  • Oxycodone
  • Phenobarbital
  • Phenytoin
  • Primidone
  • Ribociclib
  • Rifampin (rifampicin)
  • Schisandra
  • Thalidomide
  • Tricyclic Antidepressants
  • Verapamil

Cautions

Your doctor should monitor your heart rate and blood pressure while starting this medication.

Tell your doctor right away if you develop a rash while starting this drug.

Do not operate a vehicle until you know how this drug will affect you.

Use caution if you have kidney or liver problems.

Side Effects

Common adverse reactions to Intuniv can include:

  • Drowsiness 
  • Abdominal pain
  • Agitation
  • Anxiety
  • Bradycardia
  • Constipation
  • Decreased appetite
  • Depression
  • Diarrhea
  • Dizziness
  • Emotional lability
  • Fatigue
  • First-degree AV block
  • Headache
  • Hypotension
  • Increased blood pressure
  • Insomnia
  • Irritability
  • Lethargy
  • Loss of consciousness
  • Nausea
  • Nightmares
  • Orthostatic hypotension
  • Pruritus
  • Sinus arrhythmia
  • Skin rash
  • Syncope
  • Tachycardia
  • Vomiting
  • Weight gain
  • Xerostomia

References

  1. Intuniv [package insert]. Lexington, MA: Shire; 2017.


IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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