Also Known as Monodur
Only Available By Prescription
Top brand choice
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Strength
60mg
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Strength
120mg
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Top Generic choice
| Strength | Pack Size | Qty | |
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Strength
30mg
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Strength
60mg
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Strength
120mg
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Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Imdur (Isosorbide Mononitrate) is a medication classified as a nitrate. It is used to prevent angina, which is chest pain due to coronary artery disease. The drug works by relaxing and widening blood vessels, making it easier for blood to flow and deliver oxygen to the heart. Patients are typically prescribed Isosorbide Mononitrate in tablet form, taken orally. It doesn’t act quickly enough to stop an acute angina attack once it has started, which is why other medications may be prescribed for immediate relief.
| Fact Table | |
| Formula | C6H9NO6 |
| License | US FDA |
| Bioavailability | ~100% |
| Legal status | Rx-only |
| Chemical Name | 1,4:3,6-Dianhydro-D-glucitol 5-nitrate |
| Elimination half-life | ~5 hours |
| Dosage (Strength) | 30 mg, 60 mg, 120 mg extended-release tablets |
| Pregnancy | Consult a doctor (Category C) |
| Brands | Imdur, Monoket, ISMO |
| Protein binding | ~3% |
| PubChem CID | 6433227 |
| MedlinePlus | a601086 |
| ChEBI | 31652 |
| ATC code | C01DA14 |
| DrugBank | DB01020 |
| KEGG | D00712 |
| Routes of administration | Oral |
The recommended starting dose for adults is 60 mg (one tablet) once daily in the morning, with the dose potentially increased to 120 mg (two tablets) once daily if needed. Up to 240 mg may be prescribed. To reduce the risk of headache, treatment can start with 30 mg (half a tablet) daily for the first 2 to 4 days. Tablets may be taken whole or as divided halves but should not be chewed or crushed, and must be swallowed with at least half a glass of water.
Imdur contains the active ingredient Isosorbide Mononitrate.
Avoid taking or using this product if any of the following apply:
Allergy to isosorbide-5-mononitrate, nitrates, or nitrites
Severe low blood pressure or shock
Dizziness or fainting when standing up (postural hypotension)
Heart problems caused by blocked heart valves or a stiff outer heart layer (such as aortic or mitral valve narrowing or constrictive pericarditis)
High pressure in the brain
Severe anemia (very low red blood cells)
Use of medications for erectile dysfunction (such as sildenafil, tadalafil, or vardenafil)
Before using Imdur, you may want to consult a healthcare provider about the following:
Any existing health conditions
Any allergies
A list of all medications you are currently taking
Whether you are pregnant or breastfeeding
Imdur can lower your blood pressure, especially when standing up quickly. This might make you feel lightheaded, dizzy, or even cause you to faint. These symptoms are more likely if you’re dehydrated, taking diuretics, or already have low blood pressure. Use caution when getting up from sitting or lying down, and talk to your doctor if you feel unusually weak or dizzy.
Stopping Imdur suddenly may cause chest pain to return or get worse. If you and your doctor decide to stop treatment, your dose should be reduced gradually to avoid withdrawal symptoms or a spike in angina.
Imdur is not recommended for people with recent heart attacks or severe heart failure, since its effects can't be quickly reversed if problems occur. It should also be used with caution in people with narrowing of brain arteries or very low blood pressure.
This medicine may worsen breathing issues or lower oxygen levels in people with lung disease, anemia, or heart failure. Let your doctor know if you have any lung conditions or if you feel short of breath while on this medication.
Drinking alcohol while on Imdur can also increase the risk of side effects like dizziness or fainting.
The most common side effect of Imdur is headache, especially when starting treatment, but this usually gets better after a few days. Some people may also feel dizzy, lightheaded, or tired, particularly at the beginning. These effects may lessen over time, but let your doctor know if they become bothersome.
In rare cases, taking too much Imdur can cause a severe pulsing headache, nausea, vomiting, or even fainting. If this happens, lie down with your feet raised and seek medical help right away. Everyone reacts differently to medication, so let your doctor or pharmacist know if you notice any unusual side effects. Regular check-ins can help make sure the medication is working safely for you.
Imdur Product Monograph. Mississauga, ON: Juno Pharmaceuticals Corp.; 2020.
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