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Imbruvica (Ibrutinib)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Imbruvica (ibrutinib) is available by prescription only to treat certain cancers in adults. These include:

  • Mantle cell lymphoma (MCL) 
  • Chronic lymphocytic leukemia (CLL)/Small lymphocytic leukemia (SLL) 
  • Waldenström’s macroglobulinemia (WM)
  • Marginal zone lymphoma (MZL)

Imbruvica is also used in adults and pediatric patients who are at least one years old to treat chronic graft versus host disease (cGVHD).

Imbruvica comes in the following dosage forms and strengths:

  • 70 mg and 140 mg oral capsules
  • 140 mg, 280 mg, 420 mg, and 560 mg oral tablets
  • 70 mg/mL oral suspension

Imbruvica may not be right for everyone. Talk to your doctor about which treatment options may be best for you.

Fact Table






Less than 4%

Legal status


Chemical Name


Elimination half-life

4–6 hours

Dosage (Strength)



Not Recommended



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


The dosage of Imbruvica depends on the condition being treated. Take Imbruvica as prescribed by your doctor. Discuss any questions or concerns you have with your doctor or pharmacist. 

Recommended Imbruvica dosing:

MCL and MZL: 560 mg by mouth once daily

CLL/SLL and WM: 420 mg by mouth once daily

cGVHD in patients who are least 12 years old: 420 mg by mouth once daily

cGVHD in patients 1 to 11 years old: 240 mg/m2 by mouth once daily (up to a maximum dose of 420 mg)

The dose of Imbruvica may be adjusted in patients with liver problems.


Ibrutinib, a kinase inhibitor, is the active ingredient contained in each Imbruvica capsule, tablet, and oral suspension.


Imbruvica does not have any known contraindications.


  • Before you starting Imbruvica treatment, talk to your doctor about:
    • All the medications you take
    • Your allergies
    • Your medical history and health problems
    • Your pregnancy or breastfeeding status
  • Severe bleeding has been observed in patients taking Imbruvica. Monitor for signs or symptoms of bleeding such as black, tarry stools, blood in your vomit, bleeding from the gums, and nosebleeds that won't stop after 10-15 minutes of applied pressure. Seek medical care right away if any of these develop or if you have a fall or head trauma. 
  • Infections have been reported with the use of Imbruvica. 
  • Serious heart arrhythmias, heart failure, and sudden death have been reported in patients taking Imbruvica.
  • Imbruvica may cause high blood pressure.
  • Imbruvica may cause abnormal blood cell counts.
  • Skin cancers and other malignancies have been reported in patients taking Imbruvica.
  • Tumor lysis syndrome may occur during Imbruvica treatment; however, it's rare.
  • Imbruvica can cause harm to a fetus. Effective birth control methods during treatment and for one month after stopping Imbruvica is recommended for women taking Imbruvica.

Side Effects

Imbruvica side effects include abnormal blood cell counts, diarrhea, fatigue, musculoskeletal pain, rash, anemia, bruising, serious bleeding, muscle spasms, stomach pain, headache, pneumonia, and sores and swelling of the mouth; however, these are not all the side effects associated with Imbruvica use.

If you experience side effects that bother you or won't go away, contact your doctor immediately.


  1. Imbruvica (ibrutinib). South San Francisco, CA: Pharmacyclics LLC; 2022.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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