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Advil (Ibuprofen)

Also Known as Motrin

Prescription medicineOnly Available By Prescription

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Top Generic choice

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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Advil is a common medication used to treat pain (analgesic) and to lower fever (antipyretic). It is sold over-the-counter in 200 mg strength tablets. Advil is also available in the prescription strength 400 mg and 800 mg tablets.

Advil reduces inflammation by slowing down the formation of prostaglandins, which are signal molecules used by the immune system to treat pain and inflammation.

Fact Table







Legal status

US: OTC / Rx-only

Chemical Name


Elimination half-life

2–4 h

Dosage (Strength)

200mg, 300mg, 400mg


Not recommended


Advil, Motrin

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


Do not take Advil for longer than directed by your healthcare provider because it has potentially serious long-term side effects. Advil is generally considered safe with short-term use, so only use the lowest dose for the shortest amount of time.

The usual OTC Advil dose is 200 mg tablets, 1-2 tablets by mouth every four to six hours as needed for pain.


The active ingredient in Advil is ibuprofen.


Use caution if you are taking any of the following medications. Tell your doctor and pharmacist so they can determine if the combination is safe for you.

  • Aminolevulinic Acid
  • Apixaban
  • Aspirin
  • Citalopram
  • Cyclosporine
  • Dabigatran
  • Edoxaban
  • Enoxaparin
  • Fluoxetine
  • Heparin
  • Imatinib
  • Ketorolac
  • Lithium
  • Loop diuretics
  • Methotrexate
  • Naproxen
  • Paroxetine
  • Pemetrexed
  • Rivaroxaban
  • Sertraline
  • Sodium phosphates
  • Tenofovir
  • Urokinase
  • Warfarin


Use caution if you have a history of kidney or liver issues while taking Advil. 

Prolonged use of Advil can increase the risk of stomach ulcers and gastrointestinal side effects. 

Long-term use of Advil can increase the risk of heart attack and stroke.

Talk to your healthcare team about all the precautions that you should be aware of.

Side Effects

Common adverse reactions to Advil may include:

  • Abdominal cramps
  • Abdominal distress
  • Abdominal pain
  • Anemia
  • Bloating
  • Constipation
  • Decreased appetite
  • Decreased hemoglobin
  • Diarrhea
  • Dizziness
  • Dyspepsia
  • Edema
  • Epigastric pain
  • Flatulence
  • Fluid retention
  • Headache
  • Heartburn
  • Increased liver enzymes
  • Maculopapular rash
  • Nausea
  • Nervousness
  • Prolonged bleed time
  • Pruritus
  • Renal function abnormality
  • Skin rash
  • Tinnitus
  • Vomiting


Ibuprofen [package insert]. Livonia, MI: Major Pharmaceuticals; 2021.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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