Hydrea (Hydroxyurea)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


HYDREA (hydroxyurea) is a prescription chemotherapy medication. It may be prescribed for different types of cancer. HYDREA is indicated for:

  • Locally advanced squamous cell carcinomas of the head and neck, in combination with chemoradiation
  • Resistant chronic myeloid leukemia (CML)

Cancerous cells are cells of the body that have started to replicate uncontrollably. The constant replication takes resources and energy from other parts of the body and can grow into places where they negatively impact body function.

HYDREA is an antimetabolite, and it works by preventing the replication of cancerous cells.


Take HYDREA exactly as prescribed by your healthcare provider. HYDREA should only be prescribed by a doctor trained to treat cancer (oncologist).


The active ingredient in HYDREA is hydroxyurea.


HYDREA has severe drug-drug interactions with the following medications:

  • Bacillus Calmette-Guerin
  • Cladribine
  • Didanosine
  • Dipyrone
  • Natalizumab
  • Pimecrolimus
  • Stavudine
  • Tacrolimus
  • Upacitinib
  • Vaccines

Speak with your doctor or pharmacist for a full list of drug interactions


HYDREA can cause severe bone marrow suppression. Your healthcare provider should regularly monitor your blood counts.

HYDREA can cause or worsen vasculitic toxicities, like gangrene or ulcer wounds.

HYDREA may cause secondary malignancy. Use sun protection while taking this medication. The healthcare provider should monitor for symptoms of secondary malignancy.

Side Effects

Adverse reactions to HYDREA are common and can be severe. Tell the oncologist if you experience any of the following:

  • Acute mucocutaneous toxicity
  • Anemia
  • Asthma
  • Dermatological reaction
  • Eczema
  • Fever
  • Headache
  • Infection
  • Leg ulcer
  • Macrocytosis
  • Neutropenia
  • Thrombocytopenia
  • Vitamin D deficiency
  • Weight gain


Hydrea [package insert].Princeton, NJ: Bristol-Myers Squibb; 2016.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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