Humalog Mix 50

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Humalog Mix 50 is a premixed insulin formulation containing 50% insulin lispro protamine suspension (intermediate-acting) and 50% insulin lispro injection (rapid-acting). It is indicated for the treatment of diabetes mellitus in adults and children requiring insulin therapy for glycemic control. The rapid-acting component helps control postprandial glucose spikes, while the protamine-bound intermediate-acting component provides basal insulin coverage. Humalog Mix 50 offers a convenient alternative to separate basal and bolus insulin regimens in patients with consistent meal patterns.

Fact Table

Formula

C257H383N65O77S6 (insulin lispro)

License

US FDA; EMA

Bioavailability

~55–77% (subcutaneous)

Legal status

Prescription only

Chemical Name

Insulin lispro and insulin lispro protamine

Elimination half-life

Insulin lispro: ~1 hour; Protaminated form: ~5–6 hours

Dosage (Strength)

100 units/mL; 3 mL cartridges, vials, or KwikPen

Pregnancy

Category B – considered safe with monitoring

Brands

Humalog Mix50, Humalog Mix50 KwikPen (by Eli Lilly)

Protein binding

Negligible

PubChem CID

16129678 (insulin lispro)

MedlinePlus

a699001

ChEBI

CHEBI:80695

ATC code

A10AD05

DrugBank

DB01306

KEGG

D04588

Routes of administration

Subcutaneous injection

Directions

Humalog Mix 50 is administered subcutaneously, typically within 15 minutes before a meal.

Dosing is individualized based on blood glucose monitoring, metabolic needs, and clinician guidance.

It may be used once or twice daily, depending on meal timing and glycemic goals.

Rotate injection sites regularly (abdomen, thigh, upper arm) to prevent lipodystrophy.

Do not administer intravenously or use in insulin pumps. Do not mix with other insulins.

Ingredients

Each mL of Humalog Mix 50 contains:

Insulin lispro protamine suspension 50% (intermediate-acting)

Insulin lispro 50% (rapid-acting)

Other ingredients include:

Glycerin, protamine sulfate, zinc oxide, phenol, m-cresol, and water for injection

Available in:

Vials (10 mL)

KwikPen prefilled pen (3 mL)

Concentration: 100 units/mL (U-100)

Contraindications

Humalog Mix 50 is contraindicated in:

Patients with hypersensitivity to insulin lispro or any component of the formulation

Patients experiencing hypoglycemia at the time of administration

Cautions

Careful monitoring is required during insulin initiation or dosage adjustment. Dose changes may be necessary with changes in physical activity, diet, or renal/hepatic function. Hypoglycemia is the most common and serious adverse effect. Do not share pens or syringes to prevent cross-contamination. Avoid use in patients with unstable or rapidly fluctuating glucose levels, as premixed insulin may not allow for fine-tuned control.

Side Effects

Common and potential side effects include:

Hypoglycemia

Injection site reactions (e.g., redness, swelling, itching)

Lipodystrophy with repeated use at the same site

Weight gain

Edema

Rare: allergic reactions, insulin resistance, or anaphylaxis

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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