Only Available By Prescription
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4g/20ml
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10g/50ml
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Hizentra is a subcutaneous immunoglobulin (SCIg) preparation composed of a 20% solution of Immunoglobulin (Human), indicated for the treatment of primary immunodeficiency (PI) and chronic inflammatory demyelinating polyneuropathy (CIDP). Developed for self-administration, Hizentra offers flexible dosing schedules with consistent immunoglobulin G (IgG) levels and convenient home use. It is stabilized with L-proline and free from sucrose, latex, and preservatives, reducing the risk of adverse reactions in sensitive populations. Hizentra provides effective long-term immune support by supplementing IgG in patients with immune system disorders and helping to prevent serious infections and manage neurological symptoms in CIDP.
| Fact Table | |
| Formula | Polyclonal IgG (human plasma-derived) |
| License | US FDA, EMA |
| Bioavailability | Approximately 65% (subcutaneous) |
| Legal status | Prescription only (Rx) |
| Chemical Name | Immunoglobulin G (Human) |
| Elimination half-life | 25–32 days |
| Dosage (Strength) | 20% solution (200 mg/mL) |
| Pregnancy | Use only if clearly needed |
| Brands | Hizentra |
| Protein binding | Not applicable (endogenous protein) |
| PubChem CID | 16133278 |
| MedlinePlus | a610019 |
| ChEBI | 16763 |
| ATC code | J06BA01 |
| DrugBank | DB13100 |
| KEGG | D02259 |
| Routes of administration | Subcutaneous (SC) |
Hizentra is administered subcutaneously, typically once weekly or more frequently depending on clinical need. Dosage is individualized based on patient weight, clinical response, and serum IgG trough levels. For primary immunodeficiency, maintenance doses are usually calculated based on prior IVIG or SCIg therapy. For CIDP, the recommended weekly dose is based on the equivalent IVIG dose divided over the desired frequency. Infusions should be performed using an infusion pump and appropriate aseptic technique. Patients or caregivers must receive comprehensive training before beginning home infusions. Rotating infusion sites with each dose is advised to minimize local site reactions.
Hizentra contains 200 mg/mL of Immunoglobulin G (IgG), stabilized with 250 mg/mL of L-proline in a solution with a pH of 4.8. The product contains trace amounts of IgA and is preservative-free.
Hizentra is contraindicated in patients with a history of anaphylactic or severe systemic reactions to human immunoglobulin preparations. It is also contraindicated in individuals with hyperprolinemia type I or II due to the presence of L-proline in the formulation.
Caution should be exercised in patients with a history of thrombotic events, renal impairment, or those who are immobile or have predisposing risk factors for thrombosis. Although the subcutaneous route reduces the risk of some systemic side effects associated with intravenous immunoglobulin, monitoring is still necessary. Immunoglobulin products may interfere with the immune response to live vaccines, so appropriate vaccination timing should be considered. Patients should be educated on the signs of hypersensitivity reactions and advised to seek medical attention promptly if symptoms occur.
Common side effects of Hizentra include:
Serious adverse effects such as anaphylaxis, aseptic meningitis, thromboembolic events, and hemolysis have been reported but are rare. Patients should be monitored for adverse reactions, especially during initial treatments or dose adjustments.
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We pride ourselves on delivering excellent customer service with as much accessibility as possible.
If you have any questions at all, or would like to place an order, you are encouraged to contact us by toll-free
phone 1-888-904-8467 or email info@canadadrugsdirect.com.
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Canada Drugs Direct employs dedicated, professional licensed pharmacists to ensure that each and every order is reviewed before it is dispensed for the safety and health of our customers. At CanadaDrugsDirect.com, your health is our top priority.
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