GSK-3536819 (MenABCWY)

Prescription medicineOnly Available By Prescription

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Description

GSK-3536819 (MenABCWY) is a novel combination meningococcal vaccine developed by GSK to provide protection against Neisseria meningitidis serogroups A, B, C, W, and Y. This pentavalent formulation merges the immunological benefits of existing MenB and MenACWY vaccines into one comprehensive solution. Ideal for preteens, adolescents, and young adults, the MenABCWY GSK vaccine helps reduce complexity in vaccine administration and enhances compliance with CDC meningococcal vaccination guidelines. For clinics and immunization providers looking to buy MenABCWY, this product offers a clinically efficient alternative to separate MenB and MenACWY vaccinations.

Fact Table
Formula Not applicable (vaccine – biologic formulation)
License FDA approved (October 2023)
Bioavailability Not applicable (intramuscular injection)
Legal status Prescription only (Rx)
Chemical Name Meningococcal Group A, C, W, Y and B Vaccine
Elimination half-life Not applicable
Dosage (Strength) Single-dose injection (0.5 mL)
Pregnancy Consult healthcare provider
Brands Penbraya
Protein binding Not applicable
PubChem CID Not listed
MedlinePlus Not assigned
ChEBI Not available
ATC code J07AH10
DrugBank Not assigned
KEGG Not available
Routes of administration Intramuscular injection

Directions

Administered as a two-dose intramuscular series, the MenABCWY vaccine is injected into the upper arm (deltoid muscle), with the second dose given six months after the first. It is crucial to complete the series within the recommended interval to ensure optimal immune protection against all covered serogroups. Healthcare providers must follow established immunization schedules and maintain accurate patient records.

Ingredients

Each MenABCWY dose contains polysaccharide antigens from meningococcal serogroups A, C, W, and Y conjugated to CRM197, in addition to recombinant protein antigens targeting serogroup B. The formulation includes aluminum hydroxide as an adjuvant and uses a histidine buffer system with sodium chloride and sterile water. The vaccine is free from preservatives and latex.

Cautions

MenABCWY GSK should be administered with caution to individuals with a history of severe allergic reactions, neurological conditions such as Guillain-Barré Syndrome, or those with compromised immune responses. Patients experiencing an acute illness or fever should delay vaccination. For providers aiming to buy MenABCWY for distribution or public health campaigns, thorough screening of patient history is essential for safety and efficacy.

Contraindications

MenABCWY is contraindicated in individuals who have demonstrated hypersensitivity to vaccine components or any prior meningococcal vaccine containing similar antigens. A severe allergic reaction to diphtheria toxoid or CRM197 also warrants exclusion from administration.

Side Effects

Reported side effects include:

  • Injection site pain and swelling
  • Fever or chills
  • Muscle aches
  • Headache
  • Fatigue
  • Nausea

These effects are typically transient and self-limiting. Rare but serious reactions should be reported through established vaccine safety monitoring systems.

Frequently Asked Questions about MenABCWY (GSK-3536819)


What is the MenABCWY (GSK-3536819) vaccine?

MenABCWY is a vaccine that provides protection against five major serogroups of meningococcal bacteria (A, B, C, W, and Y) in a single injection.


Who should receive the MenABCWY vaccine?

The vaccine is recommended for adolescents and young adults, particularly those entering college, living in dormitories, or with certain medical conditions that increase risk of meningococcal disease.


What diseases does MenABCWY prevent?

It helps prevent meningococcal meningitis and septicemia (bloodstream infection), which can cause serious illness and death within hours if left untreated.


How is the MenABCWY vaccine administered?

It's given as a single intramuscular injection, typically in the upper arm or thigh.


What are common side effects of the MenABCWY vaccine?

Common side effects include pain/redness at the injection site, headache, fatigue, muscle pain, and mild fever, which typically resolve within a few days.


How long does protection from MenABCWY last?

Protection typically lasts several years, though exact duration may vary. Healthcare providers may recommend boosters based on risk factors.


Can MenABCWY be given at the same time as other vaccines?

Yes, it can generally be administered during the same visit as other age-appropriate vaccines, though they should be given at different injection sites.


Is MenABCWY different from previous meningococcal vaccines?

Yes, it's the first single vaccine to protect against all five major disease-causing meningococcal serogroups (previous vaccines covered either serogroup B or serogroups A, C, W, and Y).


Are there any contraindications for receiving MenABCWY?

The vaccine shouldn't be given to individuals with severe allergic reactions to any component of the vaccine or to those who had a severe reaction to a previous dose.


When will MenABCWY be widely available?

Following clinical trials and regulatory approvals, the vaccine is expected to be available through healthcare providers after receiving final authorization from regulatory agencies.

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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