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Glumetza (Metformin Extended Release)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Glumetiza is an extended-release version of the drug metformin and is usually the first medication someone tries when diagnosed with type 2 diabetes mellitus.

When someone has type 2 diabetes, their body's cells do not respond as well to insulin. They need higher levels of insulin to maintain healthy blood sugar levels. Metformin works by making cells more sensitive to the insulin already there.

Fact Table







Legal status


Chemical Name


Elimination half-life

4–8.7 hours

Dosage (Strength)

500mg, 1000mg


No Known Risk


Glucophage, Glumetza

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


The dosage ranges from 500 mg once daily to 1000 mg twice daily. Glumetza should be taken with food to minimize side effects on the stomach.


The active ingredient in Glumetza is metformin extended-release.


Tell your healthcare provider if you are taking any of the following medications:

  • Abemaciclib
  • Alcohol
  • Alpha-Lipoic Acid
  • Androgens
  • Beta-Blockers
  • Bortezomib
  • Carbonic Anhydrase Inhibitors
  • Cephalexin
  • Cimetidine
  • Dalfampridine
  • Direct Acting Antiviral Agents
  • Dofetilide
  • Dolutegravir
  • Erdafitinib
  • Etilefrine
  • Fexinidazole
  • Fludeoxyglucose F 18
  • Gilteritinib
  • Glycopyrrolate
  • Guanethidine
  • Guar Gum
  • Hyperglycemia-Associated Agents
  • Hypoglycemia-Associated Agents
  • Iodinated Contrast Agents
  • LamoTRIgine
  • Maitake
  • MATE1/2-K Inhibitors
  • Monoamine Oxidase Inhibitors
  • Nonsteroidal Anti-Inflammatory Agents
  • Ombitasvir, Paritaprevir, and Ritonavir
  • Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir
  • Ondansetron
  • Pacritinib
  • Patiromer
  • Pegvisomant
  • Prothionamide
  • Quinolones
  • Ranolazine
  • Risdiplam
  • Ritodrine
  • Salicylates
  • Selective Serotonin Reuptake Inhibitors
  • Tafenoquine
  • Thiazide and Thiazide-Like Diuretics
  • Topiramate
  • Verapamil
  • Vitamin K Antagonists


Tell your doctor if you have a history of liver or kidney problems before starting this drug. 

Metformin may need to be held for a brief period if you have surgery or receive a procedure with iodine contrast.

Side Effects

Common adverse reactions may include:

  • Abdominal distension
  • Abdominal distress
  • Abdominal pain
  • Abnormal stools
  • Asthenia
  • Chest discomfort
  • Chills
  • Diaphoresis
  • Diarrhea 
  • Dizziness
  • Dyspepsia 
  • Dyspnea
  • Encephalopathy
  • Fixed drug eruption 
  • Flatulence 
  • Flu-like symptoms
  • Flushing
  • Headache
  • Heartburn
  • Hemolytic anemia
  • Hepatic injury
  • Hypoglycemia
  • Lactic acidosis
  • Lichen planus
  • Myalgia
  • Nail disease
  • Nausea and vomiting 
  • Palpitations
  • Upper respiratory tract infection
  • Vitamin B12 deficiency


  1. Glumetza [package insert]. Menlo Park, CA: Depomed, Inc; 2009.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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