Canada Drugs Direct

Visiting from Canada?

Want to save up to 80% on your medications? Signup below to be notified if we open a Canadian Online Pharmacy.

I agree to receive email updates from Canada Drugs Direct

Looking for Call us toll free 1-800-500-2897

Glucovance (Glyburide/Metformin)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
Pack Size
Pack Size
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


GLUCOVANCE (glyburide/metformin) is a combination medication used to treat people with Type 2 Diabetes Mellitus.

People with diabetes do not produce enough insulin to meet their metabolic needs. This may be because the cells of their pancreas are not producing enough insulin, it may be because their body has developed a resistance to insulin, or it can be a combination of both.

GLUCOVANCE helps to lower blood sugar to a safer range, preventing the damage that can be caused by hyperglycemia (high blood sugar).


The starting GLUCOVANCE dosage is 1.25 mg/250 mg by mouth one to two times daily with meals. GLUCOVANCE can be increased to a maximum of 20 mg/2000 mg per day in divided doses.

Take GLUCOVANCE with meals; skipping a meal increases the risk of hypoglycemia.


The active ingredients in GLUCOVANCE are metformin and glyburide.

Metformin decreases the production of glucose by the liver and reduces the absorption of insulin from food.

Glyburide stimulates the cells of the pancreas to release more insulin.


The following medications may have drug-drug interactions with GLUCOVANCE:

  • Bosentan
  • Calcium channel blocking agents
  • Chloramphenicol
  • Corticosteroids
  • Diuretics
  • Estrogens
  • Isoniazid
  • Monoamine oxidase inhibitors (MAOIs)
  • Nicotinic acid
  • NSAIDs
  • Oral contraceptives
  • Phenothiazines
  • Phenytoin
  • Probenecid
  • Sulfonamides
  • Sympathomimetics
  • Thyroid products
  • Warfarin

Fact Table







Legal status

RX Only

Chemical Name

Glibenclamide, Metformin

Elimination half-life

6.2 hours

Dosage (Strength)

1.25mg/250mg (90 tablets), 2.5mg/500mg (90 tablets), 5mg/500mg (90 tablets)


Consult a doctor


Diabeta, Glucovance, Glynase

Protein binding


PubChem CID





Glibenclamide: 5441, Metformin: 6801

ATC code



Glibenclamide: DB01016, Metformin: DB00331


Glibenclamide: DB00331, Metformin: D04966

Routes of administration

By mouth (tablets)


GLUCOVANCE can increase the risk of lactic acidosis, a potentially fatal condition where lactic acid in the blood is too high. Avoid excessive alcohol intake while taking GLUCOVANCE. The medication should also be stopped temporarily for any procedure that uses contrast dye.

Use with caution if you have a history of cardiovascular disease.

Hypoglycemia (low blood sugar) is a severe side effect of the active ingredient glyburide. Ask your healthcare provider about the signs and symptoms of hypoglycemia.

Side Effects

Common side effects of GLUCOVANCE may include:

  • Diarrhea
  • Dizziness
  • Gastrointestinal symptoms
  • Headache
  • Hypoglycemia
  • Upper respiratory infection


Glucovance [package insert].Princeton, NJ: Bristol-Myers Squibb; 2013.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product-reviews Product Reviews