Gleostine (Lomustine)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


GLEOSTINE (Lomustine) is a chemotherapeutic agent that is prescribed to treat certain types of cancer, including:

  • Brain tumors; primary and metastatic tumors.
  • Hodgkin's lymphoma, following disease progression with initial chemotherapy.

GLEOSTINE works by attaching to DNA and RNA molecules, which are necessary for cellular replication. By attaching to these molecules, cancerous cells can divide and grow. GLEOSTINE also attaches to and inactivates proteins that are important for cellular replication.


GLEOSTINE comes in the following capsule sizes:

  • 5 mg
  • 10 mg
  • 40 mg
  • 100 mg

The dose of GLEOSTINE is 130 mg per square-meter once every six weeks. The dose is rounded to the nearest 5 mg. Take GLEOSTINE exactly as prescribed by your healthcare provider and do not take it more often than every six weeks.


The active ingredient in GLEOSTINE is lomustine.


GLEOSTINE can interact with many different medications. Speak with your healthcare provider if you are taking any of the following:

  • Baracitinib
  • BCG (Bacillus Calmette-Guerin)
  • Chloramphenicol
  • Cladribine
  • Clozapine
  • Coccidiodes immitis Skin Test
  • Deferiprone
  • Denosumab
  • Dipyrone
  • Echinacea
  • Fingolimod
  • Inebilizumab
  • Leflunomide
  • Lenograstim
  • Lipegfilgrastim
  • Mesalamine
  • Natalizumab
  • Nivolumab
  • Ocrelizumab
  • Ozanimod
  • Palifermin
  • Pidotimod
  • Pimecrolimus
  • Promazine
  • Roflumilast
  • Siponimod
  • Sipuleucel-T
  • Tacrolimus
  • Tertomotide
  • Tofacitinib
  • Trastuzumab
  • Upadacitinib
  • Vaccines

Fact Table







Legal status

RX Only

Chemical Name


Elimination half-life

Approximately 94 minutes, Metabolites have a serum half-life of 16 to 48 hours

Dosage (Strength)

10mg (20 tablets), 40mg (20 tablets)


Consult a doctor


Ceenu, Gleostine

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth (tablets)


GLEOSTINE causes bone marrow suppression (myelosuppression), which can be fatal. Blood counts must be monitored while taking this medication.

GLEOSTINE can be fatal if overdosed. Take it exactly as prescribed and no more often than every six weeks.

GLEOSTINE causes lung infiltrates and pulmonary fibrosis. Pulmonary function tests should be administered before treatment and then repeating regularly during treatment.

Long-term use of GLEOSTINE can cause secondary malignancies like acute leukemia and myelodysplasia.

Liver function and kidney function should be monitored while taking GLEOSTINE.

Women who are pregnant should not take GLEOSTINE. Do not breastfeed while taking GLEOSTINE.

Side Effects

Common adverse effects that occur with GLEOSTINE can include:

  • Alopecia
  • Ataxia
  • Blindness
  • Disorientation
  • Dysarthria
  • Lethargy
  • Nausea
  • Optic atrophy
  • Stomatitis
  • Visual disturbances
  • Vomiting


  1. Gleostine [package insert].Miami, FL: NextSource Biotechnology; 2016.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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