Genotropin (Somatropin)

Description

Genotropin is a brand name for somatropin, a form of human growth hormone produced through recombinant DNA technology. It mirrors the growth hormone naturally secreted by the pituitary gland and plays a role in stimulating growth, cell repair, and metabolism. Doctors commonly prescribe Genotropin to treat children and adults with growth hormone deficiency and associated conditions that affect growth and development. This drug is also used in cases of Prader-Willi syndrome and Turner syndrome, as well as for individuals with short stature due to unknown causes.

Directions

Genotropin should be administered under the skin (subcutaneously), ensuring proper rotation of injection sites to avoid tissue breakdown. A Genotropin pen device is typically used for this process, making it important to familiarize yourself with the specific pen's instructions for mixing and administering doses. The dose of Genotropin may vary based on the individual's condition and response to treatment, but it’s important to follow a healthcare provider's guidance closely. They'll determine the right amount, which often depends on weight and diagnosis.

Ingredients

The active substance in Genotropin is somatropin. The medication may also contain inactive ingredients, such as glycine, mannitol, and others.

Contraindications

Avoid taking or using this medication if any of the following apply:

• Known allergy to somatropin or any of its components
• Acute critical illness due to complications following open heart surgery, abdominal surgery, multiple accidental trauma, or acute respiratory failure
• Active malignancy (cancer); treatment with somatropin should be stopped in patients with active cancer
• In children with Prader-Willi syndrome who are severely obese or have severe breathing problems; these patients should also undergo sleep assessment before starting treatment.

Cautions

• Talk to a healthcare provider about any of the following before starting treatment:
• Any medications being taken
• Allergies to any substances
• Other medical conditions you have
• Whether you’re pregnant or breastfeeding
• In patients recovering from critical illnesses, the decision to continue Genotropin treatment should be based on a careful assessment of the benefits versus the potential risks.
• Prior to initiating Genotropin therapy, children diagnosed with Prader-Willi syndrome need to be checked for symptoms of upper airway obstruction and sleep apnea. The treatment should be stopped if these conditions are identified.
• In individuals with a history of tumors, there is a need to monitor for any signs of tumor growth or recurrence. Genotropin has been associated with an increased risk of cancer in those who have undergone radiation treatment to the head.
• Genotropin may reveal or worsen high blood sugar levels. It is important to monitor blood sugars levels regularly, and adjustments to diabetic medications may be necessary.
• It's crucial to screen for papilledema before starting treatment as Genotropin can cause high blood pressure in the brain. This condition is usually reversible upon dose reduction or discontinuation of therapy.
• Be aware that serious allergic reactions to Genotropin are possible. Immediate medical attention should be sought if an allergic reaction occurs.
• Adults may experience symptoms such as edema, joint pain, and carpal tunnel syndrome, which are often related to fluid retention. Adjusting the dosage of Genotropin may be necessary to manage these symptoms.
• Patients with known adrenal insufficiency should be monitored for reduced serum cortisol levels, and an increase in glucocorticoid dosage might be required.
• Treatment with Genotropin may unmask or worsen existing hypothyroidism, requiring periodic thyroid function tests.
• Look out for symptoms like a limp or hip/knee pain in children, which could indicate slipped capital femoral epiphysis, requiring immediate evaluation.
• For children with scoliosis, regular monitoring is advised to detect any worsening of the condition.
• If severe abdominal pain occurs, consider the possibility of pancreatitis and seek medical evaluation if the pain is persistent.

Side Effects

Commonly, Genotropin side effects may include swelling, joint and muscle pain, stiffness, and tingling, mainly in adults with growth hormone deficiency. These side effects are usually mild, appear early in treatment, and can often be managed by adjusting the dose.

Genotropin can also lead to more serious health concerns, such as an increased risk of tumors, changes in blood sugar levels, increased brain pressure, severe allergic reactions, and growth issues in children. It's vital to monitor for any breathing difficulties, especially in those with Prader-Willi syndrome, and to seek immediate medical attention for sudden pain or swelling in the hips or knees, or if allergic reactions occur. Regular monitoring of vision, blood sugar, and thyroid function is recommended.

References:

1. Genotropin (Somatropin) Product Monograph. Belgium NV, Rijksweg: Pfizer; 2016.
2. Genotropin (Somatropin) Drug Label Information. Belgium NV, Rijksweg: Pfizer; 2023.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....