Canada Drugs Direct

Visiting from Canada?

Want to save up to 80% on your medications? Signup below to be notified if we open a Canadian Online Pharmacy.

I agree to receive email updates from Canada Drugs Direct

Looking for Call us toll free 1-800-500-2897

Gengraf (Cyclosporine Modified)

Prescription medicineOnly Available By Prescription

Top Generic choice

Strength Pack Size Qty
Pack Size
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Gengraf is used as an anti-transplant rejection medication for several types of organ transplants. It down-regulates the immune system to prevent organ rejection. It can also be used for other conditions where the immune system is too active, like psoriasis or certain types of cancer.

Fact Table







Legal status


Chemical Name


Elimination half-life

variable (about 24 hours)

Dosage (Strength)

25mg, 5omg


No Known Risk



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


Your healthcare team will determine the dosage. The levels must be carefully controlled. Never change the dosage on your own.


The active ingredient in Gengrad is cyclosporine.


There are many interactions, including:

  • Abrocitinib
  • Aliskiren
  • Asunaprevir
  • Atorvastatin
  • Baricitinib
  • BCG Products
  • Bilastine
  • Bosentan
  • Cladribine
  • Dengue Tetravalent Vaccine
  • Deucravacitinib
  • Disulfiram
  • DOXOrubicin
  • Dronedarone
  • Elagolix
  • Elagolix, Estradiol, and Norethindrone
  • Elbasvir and Grazoprevir
  • Eplerenone
  • Erdafitinib
  • Fexinidazole
  • Filgotinib
  • Foscarnet
  • Fusidic Acid 
  • Grapefruit Juice
  • Lasmiditan
  • Lercanidipine
  • Lovastatin
  • Methotrimeprazine
  • Mifamurtide
  • MiFEPRIStone
  • Natalizumab
  • Ornidazole
  • Pacritinib
  • PAZOPanib
  • Pimecrolimus
  • Pimozide
  • Pitavastatin
  • Poliovirus Vaccine
  • Potassium-Sparing Diuretics
  • Red Yeast Rice
  • Revefenacin
  • Rubella- or Varicella-Containing Live Vaccines
  • Ruxolitinib
  • Secnidazole
  • Simeprevir
  • Simvastatin
  • Sirolimus
  • Tacrolimus
  • Talimogene Laherparepvec
  • Taurursodiol
  • Tertomotide
  • Tofacitinib
  • Topotecan
  • Treosulfan
  • Typhoid Vaccine
  • Upadacitinib
  • VinCRIStine
  • Voxilaprevir
  • Yellow Fever Vaccine


Never switch between Gengraf and other forms of cyclosporine without talking with your doctor.

Ask your doctor and pharmacist about all precautions.

Side Effects

Common side effects may include:

  • Abdominal distension 
  • Abdominal distress 
  • Abdominal pain
  • Abnormal breath sounds
  • Abnormal erythrocytes 
  • Abnormal heart sounds
  • Abscess 
  • Acne vulgaris 
  • Acute myocardial infarction
  • Anemia 
  • Angioedema 
  • Anorexia
  • Anxiety
  • Aphthous stomatitis
  • Arthralgia
  • Arthropathy
  • Asthenia
  • Bacterial infection
  • Basal cell carcinoma of the skin
  • Bleeding tendency disorder 
  • Bone fracture
  • Breast fibroadenomas 
  • Bronchospasm
  • Bursitis
  • Candidiasis
  • Carcinoma 
  • Cardiac arrhythmia
  • Cardiac failure
  • Cataract
  • Cellulitis
  • Chest pain 
  • Confusion
  • Conjunctivitis 
  • Constipation 
  • Cough 
  • Cytomegalovirus disease 
  • Deafness 
  • Decreased libido
  • Depression
  • Dermatitis
  • Diabetes mellitus
  • Diaphoresis 
  • Diarrhea 
  • Dislocation
  • Disorder of hemostatic components of blood 
  • Dizziness 
  • Drowsiness
  • Dyschromia
  • Dysgeusia 
  • Dyspepsia
  • Dysphagia
  • Dyspnea
  • Eczema
  • Edema 
  • Emotional lability
  • Enanthema
  • Enlargement of salivary glands
  • Epistaxis
  • Eructation 
  • Esophagitis 
  • Eye pain
  • Female genital tract disease
  • Fever 
  • Flatulence 
  • Flu-like symptoms 
  • Flushing 
  • Folliculitis
  • Fungal infection
  • Gastric ulcer 
  • Gastritis 
  • Gastroenteritis
  • Gingival hemorrhage 
  • Gingival hyperplasia 
  • Gingivitis
  • Glossitis 
  • Goiter 
  • Gynecomastia 
  • Headache
  • Hearing loss 
  • Hematuria
  • Hepatotoxicity 
  • Herpes simplex infection
  • Herpes zoster infection
  • Hiccups 
  • Hirsutism 
  • Hot flash
  • Hyperbilirubinemia 
  • Hyperglycemia 
  • Hyperkalemia
  • Hyperkeratosis
  • Hypersensitivity reaction 
  • Hypertension
  • Hypertrichosis 
  • Hyperuricemia 
  • Hypoesthesia
  • Hypoglycemia 
  • Hypomagnesemia 
  • Increased appetite 
  • Increased blood urea nitrogen
  • Increased libido 
  • Increased nonprotein nitrogen
  • Increased serum cholesterol 
  • Increased serum creatinine
  • Increased serum triglycerides 
  • Infection
  • Insomnia
  • Lack of concentration
  • Lethargy
  • Leukopenia 
  • Leukorrhea
  • Localized fungal infection 
  • Lower limb cramp
  • Lymphadenopathy 
  • Malaise
  • Malignant lymphoma
  • Malignant neoplasm of skin 
  • Mastalgia 
  • Menstrual disease
  • Migraine
  • Muscle spasm
  • Myalgia 
  • Nail disease (brittle fingernails)
  • Nausea 
  • Nausea and vomiting 
  • Nephrotoxicity
  • Nervousness
  • Neuropathy 
  • Night sweats
  • Nocturia 
  • Pain
  • Pancreatitis
  • Paranoid ideation
  • Paresthesia 
  • Peptic ulcer
  • Peripheral ischemia
  • Pharyngitis
  • Pneumonia 
  • Polyuria
  • Pruritus
  • Psychiatric disturbance
  • Purpuric disease 
  • Pyelonephritis 
  • Qualitative disorder of platelet function 
  • Rectal hemorrhage
  • Respiratory tract infection
  • Rhinitis 
  • Rigors 
  • Seizure 
  • Septicemia 
  • Sinusitis 
  • Skin infection 
  • Squamous cell carcinoma of the skin 
  • Stiffness
  • Synovial cyst
  • Tendinopathy
  • Thrombocytopenia
  • Tingling sensation
  • Tinnitus 
  • Tongue disease
  • Tonsillitis 
  • Tremor
  • Trichorrhexis
  • Upper gastrointestinal hemorrhage
  • Upper respiratory tract infection 
  • Urinary frequency 
  • Urinary incontinence 
  • Urinary tract infection 
  • Urinary urgency 
  • Urine abnormality 
  • Urticaria
  • Uterine hemorrhage 
  • Vertigo 
  • Vestibular disturbance 
  • Viral infection 
  • Viral infection 
  • Visual disturbance 
  • Vomiting 
  • Weight gain 
  • Weight loss 
  • Wound infection 
  • Xeroderma
  • Xerostomia 


Gengraf [package insert]. North Chicago, IL: AbbVie Inc; 2021.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product-reviews Product Reviews