Gelsyn-3 (Sodium Hyaluronate)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
16.8mg/2ml 2ml 1 syringe
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Your doctor may have prescribed Gelsyn-3 if you have osteoarthritis (OA) of the knee with associated pain. Gelsyn-3 is a professionally administered medication given in the office to help relieve knee pain.

Gelsyn-3 contains hyaluronic acid (HA), which is naturally occuring in the joints. It provides the viscoelastic properties of joints. 

Fact Table







Legal status

US: RX Only

Chemical Name

hyaluronic acid

Elimination half-life

2–6 min

Dosage (Strength)



Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration



Gelsyn-3 should be administered by a trained healthcare professional in a clinical setting. Do not attempt to administer this medication yourself.


The active ingredient in Gelsyn-3 is hyaluronic acid.


There are no known significant drug interactions with this product.


Do not use this drug if you currently have an infection of the knee joint.

Gelsyn-3 should not be used in joints other than the knee.

Gelsyn-3 should be administered by a healthcare provider under sterile conditions.

Side Effects

A full list of side effects from hyaluronic acid includes:

  • Arthropathy
  • Arthralgia
  • Bleeding at the injection site
  • Bruising at the injection site
  • Burning sensation at the injection site
  • Discomfort at the injection site
  • Dyspepsia
  • Ecchymoses
  • Eczema
  • Edema
  • Erythema at the injection site
  • Erythema of skin
  • Fine wrinkling
  • Hematoma at the injection site
  • Hyperpigmentation
  • Hypertrophy at the injection site
  • Hypertension
  • Induration at the injection site
  • Injection site blister formation
  • Injection site infection
  • Injection site nodule
  • Injection site numbness
  • Itching at the injection site
  • Joint effusion
  • Joint swelling
  • Local acneiform eruptions
  • Local dryness of skin
  • Local skin exfoliation
  • Muscle rigidity at the injection site
  • Pain at the injection site
  • Papule of skin
  • Peripheral edema
  • Presyncope
  • Pruritus
  • Rash at the injection site
  • Residual mass at the injection site
  • Skin discoloration at the injection site
  • Skin rash
  • Skin tightness
  • Swelling at the injection site
  • Tenderness at the injection site


Gelsyn-3. Pambio-Noranco, Switzerland: Institut Biochimique SA (IBSA); n.d.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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