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Gel-One (Hyaluronate)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Gel-One Cross-Linked Hyaluronate is a sterile, transparent, and viscoelastic hydrogel injection used to manage knee pain due to osteoarthritis in patients who tried other therapies and did not respond well to them, including non-steroidal anti-inflammatory drugs (NSAIDs) or over-the-counter pain relievers. 

Fact Table







Legal status


Chemical Name


Elimination half-life

17 hours to 1.5 days

Dosage (Strength)



No Known Risk



Protein binding


PubChem CID






ATC code






Routes of administration



Gel-One comes in a pre-filled 3 mL syringe (1% solution, 30 mg total hyaluronan). Each syringe is a one-time injection into the knee's intra-articular space. 

The contents of the syringe must be used right away after opening the package. Any unused Gel-One should be discarded. 

Talk to your doctor or pharmacist if you have any questions.


There is 1% (10 mg/mL) Hyaluronan solution in each 3 mL syringe.


Avoid using Gel-One if you have an allergy to sodium hyaluronate or other ingredients contained in Gel-One.

Avoid using Gel-One if you have a skin condition or infection at or near the area of injection.


  • Before you begin treatment with Gel-One, let your doctor know:
    • If you have any allergies
    • Any medications you are taking. These include all prescription and non-prescription medications, including vitamins and herbal supplements.
    • Of any medical conditions you may have
    • If you are pregnant or plan to become pregnant
    • If you are breastfeeding or plan to breastfeed
  • Gel-One should be used following a strict, sterile technique
  • Do not use Gel-One with disinfectants that contain quaternary ammonium salts for the skin. Precipitation of hyaluronate can occur.
  • Do not inject Gel-One into a vessel.
  • Do not inject Gel-One outside of the joint or into the synovial tissue and capsule. 
  • Store Gel-One in conditions below 77°F (25° C). Do not keep it in the freezer.
  • After injecting Gel-One, joint pain, swelling, and/or effusion may occur. These generally resolve on their own or with conservative treatment.
  • Do not overexert yourself within at least 48 hours of using Gel-One.

Side Effects

The most common side effects of Gel-One injections include swelling, effusion, and joint stiffness. Please immediately seek medical attention if any bothersome or persistent side effects happen.


Gel-One Package Insert.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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