Firazyr (Icatibant)

Prescription medicineOnly Available By Prescription
Sezzle

Top brand choice

Strength Pack Size Qty
Strength
30mg/3ml
Pack Size
Qty

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Firazyr is an injectable medication used to treat acute attacks of hereditary angioedema (HAE) in adults. HAE is a rare genetic condition characterized by sudden face, throat, stomach, or limbs swelling. This swelling can be life-threatening, particularly if it affects the airways.

Icatibant, the active ingredient in Firazyr, is a bradykinin B2 receptor antagonist. It works by blocking the effects of bradykinin, a substance in the body that causes blood vessels to expand, leading to the swelling and pain associated with HAE attacks. By blocking bradykinin, Firazyr prevents HAE attacks.

Fact Table

Formula

C59H89N19O13S

License

US FDA, EMA

Bioavailability

97%

Legal status

Prescription only

Chemical Name

D-Arginyl-L-prolyl-L-arginyl-D-cysteinyl-L-prolyl-D-tyrosyl-L-isoleucyl-L-seryl-D-histidyl-L-tryptophyl-L-seryl-D-threonyl-D-isoleucyl-L-arginyl-L-prolyl-D-hydroxyprolyl-L-cysteinamide, cyclic (7-17)-disulfide

Elimination half-life

1-2 hours

Dosage (Strength)

30 mg/3 mL (10 mg/mL)

Pregnancy

Consult a doctor

Brands

Firazyr

Protein binding

44%

PubChem CID

71356

MedlinePlus

a611021

ChEBI

CHEBI:63621

ATC code

B06AC02

DrugBank

DB06273

KEGG

D08068

Routes of administration

Subcutaneous

Directions

Firazyr is administered as a subcutaneous injection, usually in the abdominal area.

The standard dose is 30 mg, given as a single injection.

If symptoms persist or recur, additional doses may be administered, but no more than three doses should be given within 24 hours, and the doses should be separated by at least 6 hours.

Patients should receive training from a healthcare professional on how to self-administer the injection before using Firazyr at home.

Ingredients

The active ingredient in Firazyr is icatibant.

Interactions

Firazyr may interact with the following drugs:

  • Benazepril
  • Captopril
  • Enalapril
  • Fosinopril
  • Lisinopril
  • Moexipril
  • Perindopril
  • Quinapril
  • Ramipril
  • Trandolapril

Cautions

Before starting Firazyr, tell your doctor if you have a history of heart conditions, blood clots, or severe allergic reactions.

Firazyr should only be used during pregnancy after discussong the risks and benefits with your doctor.

Additionally, it is unknown if Firazyr passes into breast milk, so talk with your healthcare provider if you are breastfeeding.

Do not use Firazyr if you are allergic to icatibant or any other ingredients in the medication.

Side Effects

Common side effects may include:

  • Dizziness
  • Fever
  • Headache
  • Injection site disorder
  • Liver enzyme levels above the reference range
  • Nausea
  • Rash

References

Firazyr [package insert]. Lexington, MA: Shire Orphan Therapies; 2011.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product-reviews Product Reviews