Only Available By Prescription
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| Strength | Pack Size | Qty | |
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Strength
Conti 75mcg
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Strength
50mcg/24hr
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Femseven is a transdermal hormone replacement therapy (HRT) patch containing estradiol hemihydrate, a synthetic form of the naturally occurring estrogen, estradiol. It is primarily used to alleviate moderate to severe symptoms of menopause, such as hot flushes, night sweats, and vaginal dryness, which are caused by decreased estrogen levels. Femseven delivers a consistent dose of estradiol through the skin into the bloodstream, helping restore hormonal balance. This therapy is also indicated for the prevention of osteoporosis in postmenopausal women at high risk of fractures who are intolerant of or contraindicated for other osteoporosis treatments.
| Fact Table | |
| Formula | C18H24O2 • ½H2O |
| License | UK MHRA, EMA |
| Bioavailability | ~100% (transdermal) |
| Legal status | Prescription only |
| Chemical Name | Estradiol hemihydrate |
| Elimination half-life | 13–20 hours (varies with route) |
| Dosage (Strength) | Femseven 50: 50 µg/day; Femseven 75: 75 µg/day; Femseven 100: 100 µg/day |
| Pregnancy | Contraindicated |
| Brands | Femseven, Estradot, Evorel |
| Protein binding | ~98% |
| PubChem CID | 5757 |
| MedlinePlus | a605032 |
| ChEBI | 16469 |
| ATC code | G03CA03 |
| DrugBank | DB00783 |
| KEGG | D00194 |
| Routes of administration | Transdermal (patch) |
Femseven patches should be applied to clean, dry, and intact skin on the lower abdomen or buttocks, avoiding the waistline or areas exposed to sunlight. The patch should be replaced once a week, and each new patch should be applied to a different site to reduce skin irritation. Patients should follow the prescribing physician's instructions regarding the duration and dosing of treatment, and periodic evaluations should be conducted to assess the need for continued therapy.
Each Femseven patch contains estradiol hemihydrate as the active ingredient, which is released at a steady rate over a seven-day period. Inactive components of the patch include adhesive substances and the patch backing material, which are designed to ensure effective adhesion and controlled hormone delivery.
Femseven is contraindicated in women with known, suspected, or history of breast cancer, estrogen-dependent neoplasia, active or recent thromboembolic disorders (e.g., deep vein thrombosis, pulmonary embolism), undiagnosed vaginal bleeding, untreated endometrial hyperplasia, or liver dysfunction or disease. It should not be used during pregnancy or breastfeeding.
Femseven should be used with caution in patients with a history of cardiovascular disease, hypertension, diabetes, gallbladder disease, or a family history of hormone-sensitive cancers. Smoking increases the risk of serious cardiovascular side effects during HRT and should be discouraged. Regular follow-ups are recommended to monitor blood pressure, lipid profiles, and endometrial thickness, especially in long-term users.
Common side effects of Femseven may include:
Serious but rare side effects include thromboembolic events, stroke, and increased risk of breast or endometrial cancer.
What is the difference between Femseven Conti and Femseven Mono?
Femseven Mono contains only estradiol, while Femseven Conti includes both estradiol and a progestogen (levonorgestrel), making Conti suitable for women with an intact uterus to reduce endometrial cancer risk.
Is Femseven bioidentical?
Yes, Femseven contains estradiol hemihydrate, which is chemically identical to the estrogen produced naturally by the ovaries, classifying it as a bioidentical hormone replacement therapy.
Can Femseven cause breast tenderness or enlargement?
Yes, some women may experience breast tenderness or a feeling of fullness, especially when starting treatment. This is usually temporary but should be reported if it persists or worsens.
What should I know about applying Femseven to avoid skin problems?
Apply the patch to clean, dry, non-irritated skin and rotate sites with each application. Avoid lotions, powders, or oils on the area, as they can affect how well the patch adheres and absorbs.
Can Femseven affect cholesterol levels?
Femseven may have favorable effects on cholesterol, including raising HDL (“good”) cholesterol and lowering LDL (“bad”) cholesterol, but it can also increase triglycerides. Regular monitoring is important.
Is Femseven available in different strengths?
Yes, Femseven comes in multiple strengths to allow for individualized dosing. The appropriate dose is determined by symptom severity, treatment goals, and risk factors, under the supervision of a healthcare provider.
Does Femseven affect fertility or ovulation?
Femseven is used in postmenopausal women, where fertility is no longer a concern. It does not restore ovulation or fertility and is not a contraceptive.
Can Femseven cause headaches or migraines?
Headaches and migraines are possible side effects of Femseven, especially in women with a history of hormone-sensitive headaches. If these symptoms develop or worsen, consult a healthcare provider.
How does Femseven compare to oral estrogen therapy?
Femseven bypasses the liver by delivering estrogen directly through the skin, which may reduce the risk of blood clots and some metabolic side effects associated with oral estrogen therapy.
What follow-up is needed while using Femseven?
Regular follow-ups are essential while using Femseven to assess symptom control, monitor for side effects, and evaluate ongoing need. Breast exams, pelvic exams, and screenings should be done according to current guidelines.
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