Femring (Estradiol acetate)

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Strength Pack Size Qty
Strength
0.05mg
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Strength
0.1mg
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

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Description

Femring is a vaginal ring that contains a female hormone called estradiol acetate. Femring is used to treat hot flashes, vaginal irritation, and vaginal dryness in menopausal women.


Fact Table

Formula

C18H24O2

License

EU EMA

Bioavailability

Less than 5%

Legal status

Rx-Only

Chemical Name

Estradiol

Elimination half-life

13 - 36.5 hours

Dosage (Strength)

0.05mg, 0.1mg

Pregnancy

Consult Doctor

Brands

Femring

Protein binding

98%

PubChem CID

5757

MedlinePlus

a605041

ChEBI

16469

ATC code

G03CA03

DrugBank

DB00783

KEGG

D00105

Routes of administration

Ring

Directions

You or your doctor may insert Femring. Hands should be washed before and after inserting the ring. Follow the instructions that come with your prescription. Call your doctor if you need help with inserting the ring.

Femring should remain in place for 3 months. After 3 months you should remove your old ring and insert a new ring. 

Ingredients

The active ingredient in Femring is the female hormone, estradiol acetate.

Contraindications

You should not use Femring if you have any of the following conditions:

  • Undiagnosed abnormal genital bleeding
  • Known, suspect, or have a history of breast cancer
  • Have or suspect estrogen-dependent neoplasia
  • Known or a history of deep vein thrombosis or a pulmonary embolism
  • Known or have had a stroke or heart attack within the past year
  • Liver problems or liver disease
  • Allergic to estradiol acetate or any of the other ingredients in Femring
  • Pregnant or suspect you are pregnant. Tell your doctor if you plan to become pregnant

Cautions

WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS AND PROBABLE DEMENTIA FOR ESTROGEN-ALONE THERAPY

ENDOMETRIAL CANCER

There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Adding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer. Adequate diagnostic measures, including directed or random endometrial sampling when indicated, should be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding. 

CARDIOVASCULAR DISORDERS AND PROBABLE DEMENTIA

Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia. 

The Women's Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT) in postmenopausal women (50 to 79 years of age) during 7.1 years of treatment with daily oral conjugated estrogens (CE) [0.625 mg], relative to placebo. 

The Women's Health Initiative Memory Study (WHIMS) estrogen-alone ancillary study of the WHI reported increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 5.2 years of treatment with daily CE (0.625 mg)-alone, relative to placebo. It is unknown whether this finding applies to younger postmenopausal women.

In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and other dosage forms of estrogens.

Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

WARNING: CARDIOVASCULAR DISORDERS, BREAST CANCER AND PROBABLE DEMENTIA FOR ESTROGEN PLUS PROGESTIN THERAPY

Estrogens plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia. 

The WHI estrogen plus progestin substudy reported increased risks of DVT, pulmonary embolism, stroke, and myocardial infarction in postmenopausal women (50 to 79 years of age) during 5.6 years of treatment with daily oral CE (0.625 mg) combined with medroxyprogesterone acetate (MPA) [2.5 mg], relative to placebo. 

The WHI estrogen plus progestin substudy also demonstrated an increased risk of invasive breast cancer. 

The WHIMS estrogen plus progestin ancillary study of the WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with daily CE (0.625 mg) combined with MPA (2.5 mg), relative to placebo. It is unknown whether this finding applies to younger postmenopausal women. 

In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and MPA therapy and other combinations and dosage forms of estrogens and progestins.

Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

  • Tell your doctor about any allergies you have.
  • Tell your doctor about all the prescription and over-the-counter medications you take, including vitamins and herbal supplements.
  • Femring may increase your risk for gallbladder disease.
  • Femring may cause elevations in your blood calcium levels.
  • Femring may cause vision problems.
  • Tell your doctor if you have high blood pressure.
  • Tell your doctor if you have high cholesterol.
  • Tell your doctor if you have thyroid problems.
  • Tell your doctor if you are going to have surgery.
  • Tell your doctor if you are pregnant or plan to become pregnant.
  • Tell your doctor if you are breastfeeding or plan to breastfeed.

Side Effects

Femring can cause side effects such as breast pain, headache, spotting or irregular vaginal bleeding, stomach cramps, bloating, nausea, vomiting, and hair loss. These are not all the possible side effects. Contact your doctor right away if you experience side effects that are troublesome or persistent.

Seek emergency care immediately if you experience:

  • Signs and symptoms of a blood clot such as chest pain, vision problems, breathing problems, cough, pain, swelling, redness, or warmth in the leg
  • Signs and symptoms of a stroke such as weakness on one side of your body, trouble breathing, headaches, slurred speech, vision problems
  • Signs and symptoms of a heart attack such as chest pain, cold sweats, pain in the left arm, trouble breathing

References:

  1. Femring Prescribing Information. Rockaway, NJ: Warner Chilcott Inc.; 2005.
  2. Estradiol acetate vaginal ring (Femring). Cleveland Clinic. Accessed January 30, 2022. 


IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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