Exforge (Amlodipine / Valsartan)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


EXFORGE medication is a combination product with the same active ingredients as NORVASC (amlodipine) and DIOVAN (valsartan). The individual ingredients are combined into one tablet for a more convenient once-daily dosing of both medications together.

EXFORGE medication works by lowering blood pressure and the associated stress on the cardiovascular system. High blood pressure is a known risk factor for heart disease, coronary artery disease, heart failure, and stroke. By lowering chronically high blood pressure, EXFORGE medication works to prevent fatal and nonfatal cardiovascular events.

Fact Table




EU EMA, US DailyMed



Legal status


Chemical Name


Elimination half-life

6 hours

Dosage (Strength)

5/160mg, 10/160mg, 10/320 mg


Consult Doctor



Protein binding

Over 95%

PubChem CID






ATC code






Routes of administration

By mouth


EXFORGE medication should be used as directed by your physician and is typically dosed once daily. The medication should be taken with or without food at the same time each day. EXFORGE should be taken every day as directed by the prescribing physician. The effects on blood pressure may take 2-4 weeks to become noticeable and should be monitored by the physician throughout treatment.



Amlodipine alone is prescribed for the treatment of hypertension. The starting dose is amlodipine 5 mg daily and can be increased up to a maximum of amlodipine 10 mg daily. Amlodipine is a calcium-channel blocker and works by preventing the influx of calcium ions into cardiac and smooth vascular cells. Since the contractility of these cells is dependent on calcium, blockade by amlodipine relaxes both cardiac and vascular cells, decreasing blood pressure.


Valsartan is prescribed for the treatment of high blood pressure, and is initially prescribed at 80 mg to 160 mg once daily; the maximum dosage is 320 mg daily. Valsartan is an angiotensin II receptor blocker (ARB). Angiotensin II is a pressor agent that causes vasoconstriction and stimulation of cardiac muscle cells. Valsartan prevents angiotensin II from binding to its cellular target and thus prevents the hypertensive action of the pressor. Therefore, blocking angiotensin II has the net effect of lowering blood pressure.


EXFORGE medication should not be used in pregnant women, as valsartan can cause injury to the developing fetus. Consult with your physician if you become pregnant while taking EXFORGE.

If you experience hypotension (very low blood pressure), consult with your prescribing physician, as this might be an indication that the dose of EXFORGE medication needs to be decreased.

Physicians should use caution while starting EXFORGE in patients on dialysis for kidney failure, with heart failure, or those who have suffered a recent heart attack.

Side Effects

Side effects with EXFORGE medications are relatively rare and only occur in a small percentage of patients. The most common side effects seen with EXFORGE medication are peripheral edema (swelling of the legs or arms), nasopharyngitis, upper respiratory infection, and dizziness.

Other less common side effects may include:

  • Alopecia
  • Bullous dermatitis
  • Elevated liver enzymes
  • Impaired renal function and renal failure
  • Orthostatic hypotension (dizziness upon standing)
  • Rhabdomyolysis
  • Thrombocytopenia (low platelets)
  • Vasculitis
  • Vertigo

If you experience dizziness and low blood pressure while taking EXFORGE medication, please consult with your physician as this could mean the dose needs to be decreased. Other side effects may be more serious and should be discussed with your physician right away.


  1. DailyMed “AMLODIPINE package insert.” Nih.gov. Published 2017. Accessed October 22, 2019.
  2. DailyMed. “EXFORGE package insert.” Nih.gov. Published 2019. Accessed October 22, 2019.
  3. DailyMed. “VALSARTAN package insert.” Nih.gov. Published 2019. Accessed October 22, 2019.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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