Evrysdi (Risdiplam)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Evrysdi, also known by its generic name Risdiplam, is a medication prescribed to treat spinal muscular atrophy (SMA). It is the first oral medication that the Food and Drug Administration has approved for this purpose. Risdiplam works by modifying the splicing of survival of motor neuron 2 (SMN2) genes, thus increasing the production of the SMN protein, which is key for the maintenance of motor neurons. It's appropriate for use in adults, children, and infants who have been diagnosed with SMA.


Evrysdi is administered by mouth once daily following a meal. It should be taken roughly at the same time each day to maintain a consistent level of medication in the body. For infants, it is important to administer Evrysdi after breastfeeding and the drug must not be mixed with formula or milk. Daily dosages of Evrysdi are based on weight, with a maximum recommended daily dose of 5 mg.

If the patient uses a G-tube or NG-tube, they should introduce the medication directly into the tube, followed by a water flush to ensure the full dosage has been delivered. It is critical that once Evrysdi is prepared in the oral syringe, the patient should take it immediately; any medication not consumed within 5 minutes should be discarded, and a new dose prepared. When taking Evrysdi, patients should also drink water to ensure the drug has been completely swallowed.


Evrysdi contains the active ingredient Risdiplam.


No contraindications are listed on the Evrysdi medication label. However, people with a history of hypersensitivity reactions to Risdiplam or any ingredients of the formulation should avoid taking it.


  • Prior to using Evrysdi, ensure you provide your healthcare provider with the following information:
    • Existing health conditions
    • Known allergies
    • A list of all the medications you are currently taking
    • Your pregnancy or breastfeeding status
  • Avoid inhaling the powder or allowing it to contact your skin or eyes. If it does, wash the area with soap and water and rinse your eyes thoroughly.
  • When preparing or cleaning up Evrysdi, always wear disposable gloves to avoid direct contact with the medicine.
  • Evrysdi may increase the levels of drugs removed by certain protein transporters, like metformin. If you must use these drugs together, keep an eye out for increased side effects and consider lowering the dosage of the other drug as needed.
  • There is a pregnancy exposure registry available for women taking Evrysdi during pregnancy to monitor outcomes. You can register by calling 1-833-760-1098 or visiting the provided website.

Side Effects

Common side effects of Evrysdi include fever, diarrhea, and various types of skin rashes. Patients may also encounter upper respiratory tract infections, cough, and digestive issues like constipation and vomiting. These symptoms are reported across different individuals and can vary in severity.

While most side effects are manageable, Evrysdi can also cause more severe reactions. These include mouth ulcers, joint pain, and urinary tract infections, which may require medical attention. Given its broad use across various patient ages, including infants and young children, monitoring for these reactions is key. Caregivers and patients should report any severe or worsening symptoms to their healthcare provider promptly to manage and adjust treatment as necessary.


  1. Evrysdi (Risdiplam) Product Monograph. South San Francisco, CA: Genentech, Inc.; 2024.
  2. Evrysdi (Risdiplam) Drug Label Information. South San Francisco, CA: Genentech, Inc.; 2024.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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