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Estrofem (Estradiol)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Estrofem is a prescription medication commonly used for hormone replacement therapy (HRT) in women experiencing menopause. It contains estradiol, a form of estrogen hormone that plays a vital role in the female reproductive system. 

Estrofem is prescribed to alleviate symptoms associated with menopause, such as hot flashes, vaginal dryness, and mood changes. Additionally, it can help prevent osteoporosis, a condition characterized by weakened bones.


The usual dosage is 0.5-2 mg by mouth once daily. The tablet is available in 1 mg or 2 mg tabs.

Estrofem can be taken with or without food.

Do not stop taking this medication without talking to your doctor because it can precipitate symptoms of menopause.


The active ingredient in this drug is estradiol.


Common drug-drug interactions may include:

  • Amobarbital
  • Amprenavir
  • Anastrozole
  • Atazanavir
  • Butalbital
  • Carbamazepine
  • Darunavir
  • Exemestane
  • Fosamprenavir
  • Grapefruit juice
  • HIV protease inhibitors (e.g., ritonavir)
  • Indinavir
  • Letrozole
  • Lopinavir
  • Nelfinavir
  • Pentobarbital
  • Phenobarbital
  • Phenytoin
  • Rifampicin
  • Ritonavir
  • Saquinavir
  • Secobarbital
  • St. John's wort
  • Tamoxifen
  • Tipranavir


Before starting treatment with Estrofem, tell your medical history and any pre-existing conditions with your healthcare provider. Certain medical conditions, such as a history of blood clots, liver disease, or breast cancer, may contraindicate the use of Estrofem. 

Your doctor should regularly monitor you during treatment with Estrofem.

This drug is only for women experiencing menopause and should not be used by any pregnant or breastfeeding.

Using estrogen to prevent menopause symptoms can increase the risk of blood clots, stroke, and certain cancers.

Use caution if you have a history of liver or kidney problems.

Side Effects

Tell your doctor if you experience any of the following:

  • Abdominal pain
  • Breast tenderness or enlargement
  • Dizziness
  • Headache
  • Nausea
  • Vaginal bleeding or spotting
  • Vaginal discharge
  • Vaginal itching or irritation
  • Weight changes


Estrofem [package insert]. City, ST: Novo Nordisk; 2016.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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