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Estring (Estradiol)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


ESTRING (estradiol) is a medication prescribed to treat moderate to severe urogenital symptoms that are caused by vulvovaginal atrophy during postmenopause. The symptoms that ESTRING can help with include burning, dryness, pruritus, and dyspareunia.

ESTRING is a vaginal ring that contains estradiol, an estrogen hormone involved in the regulation of sex characteristics, and the menstrual cycle. Natural levels of estrogens decrease with age, and ESTRING helps to restore a more comfortable balance.

Fact Table







Legal status


Chemical Name


Elimination half-life

13 - 36.5 hours

Dosage (Strength)



Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth (tablets)


Insert one vaginal ring and leave it in place for 3 months at a time. Replace the ring every 3 months or as directed by your doctor.


The active ingredient in ESTRING in estradiol.


ESTRING should not be used if you have one or more of the following conditions:

  • Active deep vein thrombosis (DVT), pulmonary embolism (PE), or other clotting disorder
  • History of breast cancer
  • History of estrogen-dependent neoplasia
  • History of heart attack or stroke
  • Liver impairment
  • Pregnancy
  • Undiagnosed abnormal genital bleeding

Hormone replacement therapy with estrogen carries a number of risks, so tell your doctor your full medical history before starting treatment.

Side Effects

Adverse effects are relatively uncommon when taking ESTRING. When adverse effects do occur, they are most often topical because large amounts of the drug do not absorb into circulation. Some of the most common effects may include:

  • Arthropathy
  • Breast engorgement
  • Decreased libido
  • Gastrointestinal symptoms
  • Intermenstrual bleeding
  • Pruritus
  • Vaginal discomfort
  • Weight changes


  1. Estring [package insert]. New York, NY: Pfizer; 2008.

Postmenopausal Health, Healthline, April 18th, 2017. Retrieved May 2020.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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