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Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Estrace Cream (estradiol vaginal cream, USP, 0.01%) is a vaginal cream used to treat vulvar and vaginal atrophy.
It is available in 42.5 gram tubes that contain calibrated plastic applicators that deliver 1, 2, 3, or 4 grams.
The information that comes with your Estrace prescription should be read thoroughly and followed. Talk to your doctor or pharmacist if you have any questions or concerns.
Estrace vaginal cream dosage:
The typical dose is 2 g to 4 g daily for one or two weeks, then gradually decreased to half the original dosage for another week or two. A maintenance dosage of 1 g, one to three times a week, may be used after the goal of treatment is achieved.
Store Estrace at room temperature.
Keep Estrace away from children.
There is 0.1 mg of estradiol in a non liquefying base made up of purified water, propylene glycol, stearyl alcohol, white ceresin wax, mono- and di-glycerides, hypromellose 2208 (4000 cps), sodium lauryl sulfate, methylparaben, edetate di-sodium and tertiary-butylhydroquinone per gram of Estrace.
ESTROGENS INCREASE THE RISK OF ENDOMETRIAL CANCER
Close clinical surveillance of all women taking estrogens is important. Adequate diagnostic measures, including endometrial sampling when indicat- ed, should be undertaken to rule out malignancy in all cases of undiagnosed persistent or recurring abnormal vaginal bleeding. There is no evidence that the use of "natural" estrogens results in a different endometrial risk profile than synthetic estrogens at equivalent estrogen doses.
CARDIOVASCULAR AND OTHER RISKS
Estrogens with or without progestins should not be used for the prevention of cardiovascular disease.
The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo.
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported increased risk of developing probable dementia in post- menopausal women 65 years of age or older during 4 years of treatment with oral conjugated estrogens plus medroxyprogesterone acetate relative to placebo. It is unknown whether this finding applies to younger postmenopausal women or to women taking estrogen alone therapy.
Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.
Some Estrace vaginal cream side effects that are associated with the use of Estrace include abnormal vaginal bleeding, size increase of uterine leiomyomata, vaginitis, vaginal fungal infection, cervical secretion amount changes, cervical ectropion changes, application site reactions such as burning and irritation of the vulvovaginal area, genital itching, ovarian cancer, endometrial cancer, endometrial hyperplasia, breast tenderness or enlargement, discharge from the nipple, excessive milk production, fibrocystic breast changes, breast cancer, blood clots in the legs or lungs, stroke, heart attack, high blood pressure, nausea, vomiting, stomach cramps, bloating, cholestatic jaundice, increased risk of gallbladder disease, pancreatitis, enlargement of hepatic hemangiomas, melasma, chloasma, itching, rash, loss of scalp hair, unusual hair growth on the body or face, skin problems, intolerance to contact lenses, eye problems, headache, migraine, dizziness, mental depression, nervousness, mood changes, jerky and involuntary movements, worsening epilepsy, dementia, weight changes, carbohydrate intolerance, swelling, joint pain, leg cramps, changes in libido, allergic reactions, worsening asthma, and increased triglycerides. These are not all of the side effects that Estrace can cause. If you develop worrisome or persistent side effects, immediately seek medical attention.
Looking to purchase Estrace Cream at a competitive cost online? With a valid prescription, you can buy Estrace vaginal cream at Canada Drugs Direct.
Estrace Cream (estradiol vaginal cream, USP, 0.01%). Princeton, NJ: Bristol-Meyers Squibb Company; 2005.