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Estrace Vaginal Cream (Estradiol)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
0.01% (with Applicator)
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Estrace Cream (estradiol vaginal cream, USP, 0.01%) is a vaginal cream used to treat vulvar and vaginal atrophy. 

It is available in 42.5 gram tubes that contain calibrated plastic applicators that deliver 1, 2, 3, or 4 grams. 


The information that comes with your Estrace prescription should be read thoroughly and followed. Talk to your doctor or pharmacist if you have any questions or concerns. 

Estrace vaginal cream dosage:

The typical dose is 2 g to 4 g daily for one or two weeks, then gradually decreased to half the original dosage for another week or two. A maintenance dosage of 1 g, one to three times a week, may be used after the goal of treatment is achieved. 

  1. Take the cap off the tube. Do not separate plunger from applicator. 
  2. Screw the threaded end of the applicator onto the opened tube until it's secure. 
  3. Place upright so you can see the calibrated gram amounts. Squeeze the tube from the bottom gently so that the prescribed amount of Estrace Vaginal Cream gets placed into the applicator. The plunger will rise to show the amount of grams as you squeeze out the cream.
  4. Unscrew applicator from tube. Put the cap back on the tube. 
  5. Lie on your back with knees drawn up. To deliver the medication, insert the applicator deeply and gently into vagina. Once the applicator is in the vagina, press the plunger downward to its original position.
  6. To clean the applicator: Pull the plunger to remove it from the barrel. Use warm water and mild soap to clean the applicator.

Store Estrace at room temperature.

Keep Estrace away from children.


There is 0.1 mg of estradiol in a non liquefying base made up of purified water, propylene glycol, stearyl alcohol, white ceresin wax, mono- and di-glycerides, hypromellose 2208 (4000 cps), sodium lauryl sulfate, methylparaben, edetate di-sodium and tertiary-butylhydroquinone per gram of Estrace.


  • Patients who have abnormal vaginal bleeding should avoid treatment with Estrace. 
  • Patients who have certain cancers or have a history of certain cancers, including breast cancer or uterus cancer, should avoid using Estrace.
  • Patients who have blood clots or have a history of blood clots should avoid using Estrace.
  • Patients with liver problems or those who have a history of liver problems should avoid using Estrace. 
  • Patients who are allergic to estradiol or any other ingredient contained in the cream should avoid using Estrace.
  • Patients who are pregnant, think they are pregnant, or are breastfeeding should avoid using Estrace.



Close clinical surveillance of all women taking estrogens is important. Adequate diagnostic measures, including endometrial sampling when indicat- ed, should be undertaken to rule out malignancy in all cases of undiagnosed persistent or recurring abnormal vaginal bleeding. There is no evidence that the use of "natural" estrogens results in a different endometrial risk profile than synthetic estrogens at equivalent estrogen doses.


Estrogens with or without progestins should not be used for the prevention of cardiovascular disease. 

The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo.

The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported increased risk of developing probable dementia in post- menopausal women 65 years of age or older during 4 years of treatment with oral conjugated estrogens plus medroxyprogesterone acetate relative to placebo. It is unknown whether this finding applies to younger postmenopausal women or to women taking estrogen alone therapy.

Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

  • Before starting treatment with Estrace, tell your doctor:
    • About all medications you may take
    • If you have any allergies
    • About any health conditions you may have
    • If you are pregnant or plan to become pregnant
    • If you are breastfeeding or plan to breastfeed
  • The risk of cardiovascular events may be increased with the use of estrogen.
  • The risk of endometrial cancer is increased with the use of estrogens in women who have an intact uterus.
  • Postmenopausal women who use estrogens and progestins may be at increased risk of breast cancer. 
  • The use of estrogens may increase risk of gallbladder disease in postmenopausal women. 
  • Hypercalcemia in patients with breast cancer and bone cancer can occur while using estrogen.
  • Vision problems may be caused by estrogens.
  • High blood pressure can be caused by estrogens. 
  • High triglyceride levels that can lead to pancreatitis can occur with the use of estrogen therapy.
  • Caution with Estrace should be used in patients with liver problems.
  • Patients with low thyroid hormone levels may need a dose increase of their thyroid replacement medication while using estrogen.
  • Estrogens can cause fluid retention. 
  • Estrogens can cause low calcium levels.
  • Using estrogen with progestin may increase the risk of ovarian cancer.
  • Estrogens may worsen endometriosis.
  • Estrogens may worsen asthma, diabetes, epilepsy, migraine or porphyria, system lupus erythematosus, hepatic hemangiomas.

Side Effects

Some Estrace vaginal cream side effects that are associated with the use of Estrace include abnormal vaginal bleeding, size increase of uterine leiomyomata, vaginitis, vaginal fungal infection, cervical secretion amount changes, cervical ectropion changes, application site reactions such as burning and irritation of the vulvovaginal area, genital itching, ovarian cancer, endometrial cancer, endometrial hyperplasia, breast tenderness or enlargement, discharge from the nipple, excessive milk production, fibrocystic breast changes, breast cancer, blood clots in the legs or lungs, stroke, heart attack, high blood pressure, nausea, vomiting, stomach cramps, bloating, cholestatic jaundice, increased risk of gallbladder disease, pancreatitis, enlargement of hepatic hemangiomas, melasma, chloasma, itching, rash, loss of scalp hair, unusual hair growth on the body or face, skin problems, intolerance to contact lenses, eye problems, headache, migraine, dizziness, mental depression, nervousness, mood changes, jerky and involuntary movements, worsening epilepsy, dementia, weight changes, carbohydrate intolerance, swelling, joint pain, leg cramps, changes in libido, allergic reactions, worsening asthma, and increased triglycerides. These are not all of the side effects that Estrace can cause. If you develop worrisome or persistent side effects, immediately seek medical attention. 

Looking to purchase Estrace Cream at a competitive cost online? With a valid prescription, you can buy Estrace vaginal cream at Canada Drugs Direct


Estrace Cream (estradiol vaginal cream, USP, 0.01%). Princeton, NJ: Bristol-Meyers Squibb Company; 2005.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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