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Estalis (Estradiol / Norethindrone)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Your doctor may prescribe Estalis to treat the symptoms of menopause. It is commonly prescribed near the beginning stages of menopause when symptoms appear.

It contains two active ingredients: estradiol and norethisterone acetate. Estradiol is a form of estrogen that helps regulate a woman's reproductive system. Norethisterone acetate is a form of progestin, another hormone that plays a role in the menstrual cycle.

Fact Table




US DailyMed


50% - 100%

Legal status


Chemical Name

Estradiol/norethisterone acetate

Elimination half-life

12-14 hours

Dosage (Strength)

LD 0.5/0.1mg 3 months, LD 1.0/0.5mg 1 month, 1.0/0.5mg 3 months


Consult Doctor



Protein binding

37- 61%

PubChem CID






ATC code






Routes of administration

By mouth


The dosage forms are:

  • Estalis 140/50 mg patch
  • Estalis 250/50 mg patch

Estalis patches are applied twice weekly to rotating sites on the buttocks or abdomen. Each patch should be worn for 3-4 days of the week.

Your healthcare provider will determine the most appropriate dose for you based on your response to treatment.


The active ingredients in Estalis are estradiol and norethindrone acetate.


Common interactions with Estalis may include the following:

  • Anastrozole
  • Cosyntropin
  • Dehydroepiandrosterone
  • Exemestane
  • Fexinidazole
  • Fusidic Acid (Systemic)
  • Growth Hormone Analogs
  • Hemin
  • MetyraPONE
  • Ospemifene


Tell your healthcare provider if you have a history of blood clots, stroke, or heart disease before using Estalis. The medication can increase the risk of these conditions, especially in women over 35 or those with certain risk factors.

Estalis should only be used by women who have started menopause.

Side Effects

Tell your doctor if you experience the following while taking Estalis:

  • Abdominal pain
  • Abnormal pap smear
  • Acne vulgaris
  • Application site reaction
  • Arthralgia
  • Back pain
  • Breast hypertrophy
  • Bronchitis
  • Constipation
  • Depression
  • Diarrhea
  • Dizziness
  • Dysmenorrhea
  • Dyspepsia
  • Emotional lability
  • Endometrial hyperplasia
  • Flatulence
  • Flu-like symptoms
  • Gastroenteritis
  • Headache
  • Hypermenorrhea
  • Infection
  • Insomnia
  • Leukorrhea
  • Limb pain
  • Mastalgia
  • Menstrual disease
  • Nasopharyngitis
  • Nausea
  • Nervousness
  • Ovarian cyst
  • Pain
  • Peripheral edema
  • Pharyngitis
  • Postmenopausal bleeding
  • Respiratory tract disease
  • Rhinitis
  • Sinusitis
  • Skin rash
  • Upper respiratory tract infection
  • Uterine fibroids
  • Vaginal hemorrhage
  • Vaginitis
  • Viral infection
  • Vulvovaginal candidiasis
  • Weakness
  • Weight gain


  1. Estalis[package insert]. Dorval, Quebec: Novartis; 2014.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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