Esbriet (Pirfenidone)

Prescription medicineOnly Available By Prescription

Top Generic choice

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Esbriet (Pirfenidone) is a prescription medication classified as a pyridone. It works by reducing the formation of fibrosis and slowing the progression of idiopathic pulmonary fibrosis (IPF), a lung condition that causes scarring of the lungs. Esbriet may help manage IPF symptoms and is available with a doctor's prescription, and it can be purchased in tablet or capsule forms.

Fact Table




US DailyMed, EU EMA



Legal status


Chemical Name


Elimination half-life

2.4 hours

Dosage (Strength)

200mg, 267mg, 600mg, 801mg


Consult Doctor



Protein binding


PubChem CID






ATC code



Not Available



Routes of administration



The usual recommended dosage of Esbriet is three capsules or tablets, each containing 267 mg, taken three times every day with food These doses should be taken at the same times each day, specifically in the morning, afternoon, and evening. Take the medication as directed by a healthcare provider and follow the instructions given on the prescription label.


Esbriet is a medication that consists of a single active ingredient called pirfenidone.


No contraindications are indicated on the drug label. However, individuals with severe liver disease or end-stage kidney stage should avoid taking Esbriet.


  • Before starting Esbriet, tell your doctor:
    • About any medications you take, especially those that may interact with Esbriet
    • About any medical conditions you have, including liver or kidney problems
    • If you are a smoker, as this can affect Esbriet's effectiveness
    • If you are pregnant or plan to become pregnant, as Esbriet's safety during pregnancy is unknown
    • If you are breastfeeding or plan to breastfeed, as the effects of Esbriet on breastmilk are not known
  • The use of Esbriet may affect liver function and alter liver enzyme levels. A healthcare provider may reduce the dosage or discontinue the drug in some cases.
  • Increased sensitivity to sunlight may occur while taking Esbriet, requiring the use of protective clothing and sunscreen.
  • Gastrointestinal problems like nausea, vomiting, or diarrhea may be triggered by Esbriet.
  • Esbriet's effectiveness might be affected in people who smoke, potentially requiring an adjustment in treatment or dosage.

Side Effects

Esbriet may cause side effects. Common side effects may include nausea, rash, stomach pain, upper respiratory tract infection, diarrhea, and fatigue. Additionally, some patients may experience abdominal distention, abdominal pain, dizziness, gastroesophageal reflux disease, vomiting, weight loss, anorexia, pruritus, skin photosensitivity, and decreased appetite.

Esbriet may also cause more serious side effects that require immediate medical attention, such as severe skin reactions like skin blisters, rashes, mouth sores, and hives. Gastrointestinal problems, including nausea, vomiting, diarrhea, indigestion, heartburn, and stomach pain, may also be experienced by some people. If you or a loved one is taking Esbriet and experiences any of these serious side effects, seek medical advice immediately.


  1. Esbriet Prescribing Information. Brisbane, CA: InterMune, Inc.; 2023.
  2. Esbriet Safety Information. Genentech. Accessed August 9, 2023.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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