Esbriet (Pirfenidone)

Description

Esbriet (Pirfenidone) is a prescription medication classified as a pyridone. It works by reducing the formation of fibrosis and slowing the progression of idiopathic pulmonary fibrosis (IPF), a lung condition that causes scarring of the lungs. Esbriet may help manage IPF symptoms and is available with a doctor's prescription, and it can be purchased in tablet or capsule forms.

Directions

The usual recommended dosage of Esbriet is three capsules or tablets, each containing 267 mg, taken three times every day with food These doses should be taken at the same times each day, specifically in the morning, afternoon, and evening. Take the medication as directed by a healthcare provider and follow the instructions given on the prescription label.

Ingredients

Esbriet is a medication that consists of a single active ingredient called pirfenidone.

Contraindications

No contraindications are indicated on the drug label. However, individuals with severe liver disease or end-stage kidney stage should avoid taking Esbriet.

Cautions

• Before starting Esbriet, tell your doctor:
• About any medications you take, especially those that may interact with Esbriet
• About any medical conditions you have, including liver or kidney problems
• If you are a smoker, as this can affect Esbriet's effectiveness
• If you are pregnant or plan to become pregnant, as Esbriet's safety during pregnancy is unknown
• If you are breastfeeding or plan to breastfeed, as the effects of Esbriet on breastmilk are not known
• The use of Esbriet may affect liver function and alter liver enzyme levels. A healthcare provider may reduce the dosage or discontinue the drug in some cases.
• Increased sensitivity to sunlight may occur while taking Esbriet, requiring the use of protective clothing and sunscreen.
• Gastrointestinal problems like nausea, vomiting, or diarrhea may be triggered by Esbriet.
• Esbriet's effectiveness might be affected in people who smoke, potentially requiring an adjustment in treatment or dosage.

Side Effects

Esbriet may cause side effects. Common side effects may include nausea, rash, stomach pain, upper respiratory tract infection, diarrhea, and fatigue. Additionally, some patients may experience abdominal distention, abdominal pain, dizziness, gastroesophageal reflux disease, vomiting, weight loss, anorexia, pruritus, skin photosensitivity, and decreased appetite.

Esbriet may also cause more serious side effects that require immediate medical attention, such as severe skin reactions like skin blisters, rashes, mouth sores, and hives. Gastrointestinal problems, including nausea, vomiting, diarrhea, indigestion, heartburn, and stomach pain, may also be experienced by some people. If you or a loved one is taking Esbriet and experiences any of these serious side effects, seek medical advice immediately.

References:

1. Esbriet Prescribing Information. Brisbane, CA: InterMune, Inc.; 2023.
2. Esbriet Safety Information. Genentech. Accessed August 9, 2023.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....