Epuris (Isotretinoin)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Epuris is a prescription acne treatment medication used to treat nodular acne and inflammatory acne. It is a Vitamin A derivative and acne retinoid that inhibits sebaceous glands in the skin so the produce less sebum and pores are less clogged with it as a result. Excess sebum also creates an environment where the bacteria that causes acne is more able to thrive and limiting that is also a part of how Epuris works for effective acne treatment. This medication may also be prescribed to treat recalcitrant acne or acne conglobata. With isotretinoin it is important to understand that acne may initially become worse before improvements are seen.

You can buy isotretinoin for acne with a prescription, and your best price on it will be when you order medication online from Canada Drugs Direct.


The usual starting daily dose is 0.5 mg per kilogram of body weight taken daily for a period of 2 to 4 weeks. Dosage may then be adjusted based on body weight, severity of acne, and your response to the medication. Epuris should be taken as a single dose or in 2 divided doses during the day.

Isotretinoin should be taken with food.


The active ingredient in Epuris is Isotretinoin.


Inform your doctor if you have any history of kidney or liver problems, high blood cholesterol, excessively high Vitamin A levels, or you are taking tetracycline antibiotics before beginning on Epuris.

Isotretinoin should not be used by women who are pregnant or planning to become pregnant, and this is because of the risk of serious birth defects. A woman should not use Isotretinoin in any form unless approved by a doctor and she uses effective birth control without any interruption for one month before, during, and for one month after stopping isotretinoin.

Isotretinoin increases skin sun sensitivity and using sun protection and / or shading over your face while taking this medication is advisable if you will have prolonged time in the sun with exposed facial skin or elsewhere on your body where you are treating acne.

Medication may cause dry eyes, digestive system irritation, increased blood lipids (cholesterol), or decreased night vision.

In the event you miss a dose, do not take a make-up dose of the medication. Resume taking the medication the next day at the same time. Frequently missing daily doses of isotretinoin will significantly take away from the effectiveness with acne reduction.

Medication should be stored at room temperature and out of reach of children


Isotretinoin interactions between Epuris and other Rx or OTC medications are possible, and they include acitretin / carbamazepine / vitamin A / phenytoin / porfimer / progestin-only birth control pills / St. John's wort / tetracycline antibiotics like doxycycline, minocycline, tetracycline / tigecycline / tretinoin. Inform your doctor of all medications you are currently taking before getting a prescription and proceeding to buy isotretinoin for acne.

Side Effects

Isotretinoin side effects may occur and some users may experience dry eyes, dry or itchy skin, dry mouth or nose, flaking skin, increased sensitivity of skin to sunlight, nosebleeds, peeling of skin on palms of hands or soles of feet, stomach upset, thinning of hair, or unusual tiredness. If Isotretinoin side effects are experienced it may be best to discontinue use and speak to your doctor again about nodular acne treatment medication alternatives.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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