Epiduo Gel

Description

Epiduo Gel combines two active ingredients, Adapalene and Benzoyl Peroxide to treat acne vulgaris. Adapalene is a type of retinoid which aids in the renewal of skin surface, while Benzoyl Peroxide has antibacterial properties and helps to reduce oil production in the skin. Classified as a topical retinoid and antimicrobial combination, this gel is suitable for use by individuals nine years of age and older. It specifically targets the blockages in hair follicles that contribute to acne, working to alleviate redness, inflammation, and prevent new acne from forming.

Directions

The typical Epiduo Gel dosage encompasses applying a thin layer of the gel to the affected region once daily, preferably in the evening or as directed by their healthcare provider. It’s important to wash the skin with a gentle cleanser and pat dry before application. Hand washing after applying the gel will help to prevent irritation to other areas. Avoiding contact with the eyes, lips, and mucous membranes is crucial. Also, exposure to sunlight, including sunlamps, should be minimized; using sunscreen and protective clothing over the treated areas is advisable when sun exposure cannot be avoided.

Ingredients

Epiduo Gel is a topical medication that consists of two active ingredients: Adapalene and Benzoyl Peroxide.

Contraindications

No contraindications are listed on the drug label. Still, those with a known allergy or hypersensitivity to Benzoyl Peroxide, Adapalene, or any other component in the formulation should not use this product.

Cautions

• Before initiating treatment with Epiduo Gel, make sure to disclose the following to your healthcare provider:
• Any existing health conditions
• Known allergies
• A complete list of medications you are currently using
• Your status regarding pregnancy or breastfeeding

• Limit your exposure to sunlight and artificial UV light like sunlamps when using Epiduo gel. If you must be outside, use sunscreen and wear protective clothing such as a hat.
• Exposure to extreme weather conditions such as wind or cold may irritate your skin when using Epiduo gel.
• You may experience mild to moderate skin reactions like redness, peeling, dryness, and a sensation of burning or stinging, especially during the first month of use. These reactions typically decrease over time.
• If you experience severe skin irritation, you can use a moisturizer, apply Epiduo gel less frequently, or stop using it altogether.
• Do not apply Epiduo gel to wounds, eczema-affected skin, or sunburned areas.
• Avoid waxing as a method of hair removal on areas treated with Epiduo gel.
• Refrain from using other potentially irritating products such as abrasive soaps, alcohol-based products, and cosmetics with strong drying effects while using Epiduo gel.

Side Effects

Epiduo Gel can lead to several skin-related side effects. Users often report dry skin, with occurrences higher in those using Epiduo (7%) than those using a placebo gel (2%). Skin reactions such as contact dermatitis, burning sensations at the application site, and general skin irritation have been noted, generally peaking within the first week and decreasing over time.

In rarer cases, more serious side effects have occurred. These include symptoms such as eyelid swelling, severe sunburn, skin blisters, and intense itching. Facial swelling, conjunctivitis, skin discoloration, throat tightness, and allergic reactions have also been reported. These serious side effects generally warrant immediate medical attention, especially if they interfere with daily activities.

References:

1. Epiduo Gel Product Monograph. Fort Worth, Texas: Galderma Laboratories, L.P.; 2013.
2. Epiduo Gel Drug Label Information. Fort Worth, Texas: Galderma Laboratories, L.P.; 2018.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....